James E. Phillips
Pfizer
8 Papers
46 Citations
James E. Phillips is an academic researcher from Pfizer. The author has contributed to research in topics: Scale (ratio) & Hydroxymethyl. The author has an hindex of 7, co-authored 8 publications.
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Papers
Evaluation of Kilogram-Scale Sonagashira, Suzuki, and Heck Coupling Routes to Oncology Candidate CP-724,714
David H. Brown Ripin,Dennis E. Bourassa,Thomas Andrew Brandt,Michael J. Castaldi,Heather N. Frost,Joel M. Hawkins,Phillip J. Johnson,Stephen S. Massett,Karin Neumann,James E. Phillips,Jeffery W. Raggon,Peter Robert Rose,Jennifer Lea Rutherford,Barbara J. Sitter,A. Morgan Stewart,Michael G. Vetelino,Lulin Wei +16 more
TL;DR: In this article, a convergent and selective synthesis of the anti-cancer compound 2-methoxy-N-(3-{4]-3-methyl-4-(6methyl-pyridin-3-yloxy)phenylamino]quinazolin-6-yl}-E-allyl)acetamide (CP-724,714) was described.
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Development of a Practical and Convergent Process for the Preparation of Sulopenem
Steven J. Brenek,Stephane Caron,Esmort Chisowa,Mark P. Delude,Michele T. Drexler,Marcus Ewing,Handfield Robert Eugene,Nathan D. Ide,Durgesh V. Nadkarni,Jade D. Nelson,Mark Olivier,Hahdi H. Perfect,James E. Phillips,John J. Teixeira,R. Matt Weekly,John P. Zelina +15 more
TL;DR: In this paper, a convergent process for the large-scale preparation of sulopenem was proposed, where cyclization of an oxalimide intermediate was used to provide the thiopenem core.
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Synthesis and Purification of 6-Ethoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic Acid Benzylamide
Justin Beaudin,Dennis E. Bourassa,Paul Bowles,Michael J. Castaldi,Ronald J. Clay,Michel Couturier,Gregory Lee Karrick,Teresa W. Makowski,Ruth E. McDermott,Meltz Clifford Nathaniel,Morgan Meltz,James E. Phillips,John A. Ragan,David H. Brown Ripin,Robert A. Singer,John L. Tucker,Lulin Wei +16 more
TL;DR: In this paper, the synthesis of 6-ethoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid benzylamide (1) on multikilogram scale is described.
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Route Development and Bulk Synthesis of CP-865,569
Katherine Belecki,Martin A. Berliner,Richard Todd Bibart,Cliff Meltz,Karl Ng,James E. Phillips,David H. Brown Ripin,Michael G. Vetelino +7 more
TL;DR: In this paper, the synthesis of zwitterionic CP-865,569 by three different synthetic routes is described, and the synthesis strategy was primarily driven by the need to introduce the sulfonic acid functionality at the final stage of the synthesis due to the high water solubility and low organic solubilities of the desired product.
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A PRACTICAL LARGE SCALE SYNTHESIS OF 9-(HYDROXYMETHYL)- FLUORENE-4-CARBOXYLIC ACID (HOFmCO2H)
TL;DR: In this article, the title compound was prepared in 83% chemical yield with excellent chemical purity, and it was shown that it can be used to produce a very high chemical purity.
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