James E. Bowe

TL;DR: Information is gathered on the currently used experimental animal models of both Type 1 and Type 2 diabetes and their advantages and disadvantages for research purposes and details the factors that should be taken into account in their use.

TL;DR: Observations suggest that the regulation of the vasomotor response by oestrogens and phytoestrogens is mediated, at least in part, by peripheral mechanisms involving both ERalpha and ERbeta.

TL;DR: The observations suggest that neither typical protein kinase C isoforms nor p38 MAPK are involved in the potentiation of glucose-induced insulin release by kisspeptin, but intracellular signalling pathways involving phospholipase C, p42/44 MAPK and increased [Ca2+]i are required for the stimulatory effects on insulin secretion.

TL;DR: Investigation of cannabinoid receptor expression by mouse islet β-and α-cells and the effects of selective receptor agonists on cyclic AMP and calcium levels, and on dynamic insulin secretory responses found that mouse islets expressed both CB1 and CB2 receptors, and they were localised to β-cells.