James D. Stewart
University of North Carolina at Chapel Hill
38 Papers
158 Citations
James D. Stewart is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Medicine & DNA methylation. The author has an hindex of 19, co-authored 38 publications.
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Papers
An epigenetic biomarker of aging for lifespan and healthspan
Morgan E. Levine,Ake T. Lu,Austin Quach,Brian H. Chen,Themistocles L. Assimes,Stefania Bandinelli,Lifang Hou,Andrea A. Baccarelli,James D. Stewart,Yun Li,Eric A. Whitsel,James G. Wilson,Alex P. Reiner,Abraham Aviv,Kurt Lohman,Yongmei Liu,Luigi Ferrucci,Steve Horvath +17 more
- 01 Apr 2018
TL;DR: A new epigenetic biomarker of aging, DNAm PhenoAge, is developed that strongly outperforms previous measures in regards to predictions for a variety of aging outcomes, including all-cause mortality, cancers, healthspan, physical functioning, and Alzheimer's disease.
DNA methylation GrimAge strongly predicts lifespan and healthspan.
Ake T. Lu,Austin Quach,James G. Wilson,Alexander P. Reiner,Abraham Aviv,Ken Raj,Lifang Hou,Andrea A. Baccarelli,Yun Li,James D. Stewart,Eric A. Whitsel,Themistocles L. Assimes,Luigi Ferrucci,Steve Horvath +13 more
- 21 Jan 2019
TL;DR: Using large scale validation data from thousands of individuals, it is demonstrated that DNAm GrimAge stands out among existing epigenetic clocks in terms of its predictive ability for time-to-death, and a novel measure of epigenetic age acceleration, AgeAccelGrim.
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Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Austin Quach,Morgan E. Levine,Toshiko Tanaka,Ake T. Lu,Brian H. Chen,Luigi Ferrucci,Beate Ritz,Stefania Bandinelli,Marian L. Neuhouser,Jeannette M. Beasley,Linda Snetselaar,Robert B. Wallace,Philip S. Tsao,Devin Absher,Themistocles L. Assimes,James D. Stewart,Yun Li,Lifang Hou,Andrea A. Baccarelli,Eric A. Whitsel,Steve Horvath +20 more
- 14 Feb 2017
TL;DR: Overall, the epigenetic age analysis of blood confirms the conventional wisdom regarding the benefits of eating a high plant diet with lean meats, moderate alcohol consumption, physical activity, and education, as well as the health risks of obesity and metabolic syndrome.
Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
Steve Horvath,Junko Oshima,Junko Oshima,George M. Martin,Ake T. Lu,Austin Quach,Howard Cohen,Sarah Felton,Mieko Matsuyama,Donna Lowe,Sylwia Kabacik,James G. Wilson,Alexander P. Reiner,Anna Maierhofer,Julia Flunkert,Abraham Aviv,Lifang Hou,Andrea A. Baccarelli,Yun Li,James D. Stewart,Eric A. Whitsel,Luigi Ferrucci,Shigemi Matsuyama,Ken Raj +23 more
- 01 Jul 2018
TL;DR: A novel and highly robust DNAm age estimator for human fibroblasts, keratinocytes, buccal cells, endothelial cells, lymphoblastoid cells, skin, blood, and saliva samples that uncovered an epigenetic age acceleration with a magnitude below the sensitivity levels of other DNAm-based biomarkers.
DNA methylation-based estimator of telomere length.
Ake T. Lu,Anne Seeboth,Pei-Chien Tsai,Pei-Chien Tsai,Pei-Chien Tsai,Dianjianyi Sun,Dianjianyi Sun,Austin Quach,Alexander P. Reiner,Charles Kooperberg,Luigi Ferrucci,Lifang Hou,Andrea A. Baccarelli,Yun Li,Sarah E. Harris,Janie Corley,Adele M. Taylor,Ian J. Deary,James D. Stewart,Eric A. Whitsel,Themistocles L. Assimes,Themistocles L. Assimes,Wei Chen,Shengxu Li,Massimo Mangino,Jordana T. Bell,James G. Wilson,Abraham Aviv,Riccardo E. Marioni,Ken Raj,Steve Horvath +30 more
- 18 Aug 2019
TL;DR: Leukocyte DNAmTL is not only an epigenetic biomarker of replicative history of cells, but a useful marker of age-related pathologies that are associated with it and is more strongly associated with age than measured leukocyte TL (LTL).