James D. Sheehan
Harvard University
5 Papers
36 Citations
James D. Sheehan is an academic researcher from Harvard University. The author has contributed to research in topics: Motion sickness & Brain morphometry. The author has an hindex of 5, co-authored 5 publications.
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Papers
The Brain Circuitry Underlying the Temporal Evolution of Nausea in Humans
Vitaly Napadow,James D. Sheehan,Jieun Kim,Lauren LaCount,Kyungmo Park,Ted J. Kaptchuk,Bruce R. Rosen,Braden Kuo +7 more
TL;DR: While phasic activation in fear conditioning and noradrenergic brainstem regions precipitates transition to strong nausea, sustained activation following this transition occurs in a broader interoceptive, limbic, somatosensory, and cognitive network, reflecting the multiple dimensions of this aversive commonly occurring symptom.
Brain white matter microstructure is associated with susceptibility to motion‐induced nausea
Vitaly Napadow,James D. Sheehan,Jieun Kim,Allison Dassatti,Andrea H. Thurler,Brian Surjanhata,Mark Vangel,Nikolaos Makris,Judith D. Schaechter,Braden Kuo +9 more
TL;DR: Differences in white matter microstructure within tracts connecting visual motion and nausea‐processing brain areas may contribute to nausea susceptibility or may have resulted from an increased history of nausea episodes.
Pooled analysis of brain activity in irritable bowel syndrome and controls during rectal balloon distension.
TL;DR: This work analyzed the literature to evaluate and compare the aspects of brain activity in individuals with IBS and control subjects experiencing controlled rectal stimulation to suggest an abnormal brain–gut communication.
Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea
Roberta Sclocco,Jieun Kim,Ronald G. Garcia,James D. Sheehan,Florian Beissner,Anna M. Bianchi,Sergio Cerutti,Braden Kuo,Riccardo Barbieri,Vitaly Napadow +9 more
TL;DR: Autonomic outflow and the central autonomic network underlying ANS response to nausea may be an important determinant of overall nausea intensity and, ultimately, a potential therapeutic target.
Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology
Yumi Maeda,Yumi Maeda,Norman W. Kettner,James D. Sheehan,Jieun Kim,Stephen Cina,Cristina Malatesta,Jessica Gerber,Claire McManus,Pia Mezzacappa,Leslie R. Morse,Joseph Audette,Vitaly Napadow,Vitaly Napadow +13 more
TL;DR: This study identified clear morphometric changes in the CTS brain, likely secondary to peripheral nerve pathology and altered somatosensory afference, and structural plasticity was correlated with NCV and not symptomatology, the former may be a better determinant of appropriate clinical intervention for CTS.