James D. Lederman
The Neurosciences Institute
3 Papers
James D. Lederman is an academic researcher from The Neurosciences Institute. The author has contributed to research in topics: Cholinergic & Optogenetics. The author has an hindex of 2, co-authored 2 publications. Previous affiliations of James D. Lederman include Stony Brook University.
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Papers
Cholinergic Signaling Controls Conditioned Fear Behaviors and Enhances Plasticity of Cortical-Amygdala Circuits
Li Jiang,Li Jiang,Srikanya Kundu,Srikanya Kundu,James D. Lederman,James D. Lederman,Gretchen Y. López-Hernández,Gretchen Y. López-Hernández,Elizabeth C. Ballinger,Shaohua Wang,Shaohua Wang,David A. Talmage,David A. Talmage,Lorna W. Role,Lorna W. Role +14 more
TL;DR: Stimulation of cholinergic terminal fields within the BLA in awake-behaving mice during training in a cued fear-conditioning paradigm slowed the extinction of learned fear as assayed by multi-day retention of extinction learning.
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Lack of Belonging Predicts Depressive Symptomatology in College Students
Janine M. Dutcher,James D. Lederman,Megha Jain,Stephen Allen Price,Agam Kumar,Daniella K. Villalba,Michael J. Tumminia,Afsaneh Doryab,Kasey G. Creswell,Eve A. Riskin,Yasaman Sefdigar,Woosuk Seo,Jennifer Mankoff,Sheldon Cohen,Anind K. Dey,J. David Creswell +15 more
TL;DR: This article found that lower levels of daily-assessed feelings of belonging early and across the academic term predicted higher depressive symptoms at the end of the term, and these relationships held when models controlled for baseline depressive symptoms, sense of social fit, and other social factors (loneliness and frequency of social interactions).
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Optogenetic studies of nicotinic contributions to cholinergic signaling in the central nervous system.
TL;DR: Overall, it is believed that optogenetic manipulation of cholinergic excitability in combination with some rigorous pharmacology will ultimately advance the understanding of the many functions of nAChRs in the brain.
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