James C. Comolli
Charles Stark Draper Laboratory
9 Papers
7 Citations
James C. Comolli is an academic researcher from Charles Stark Draper Laboratory. The author has contributed to research in topics: Aspergillosis & Biology. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of James C. Comolli include University of Massachusetts Medical School.
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Papers
A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control
Jonathan R. Coppeta,Mark J. Mescher,Brett C. Isenberg,Abigail June Spencer,Ernest S. Kim,Amanda R. Lever,T J Mulhern,Rachelle Prantil-Baun,James C. Comolli,Jeffrey T. Borenstein +9 more
TL;DR: Stable biological function for multiple pairs of airway-liver models for periods of 2 weeks in the platform is demonstrated, with precise control over fluid levels, temperature, flow rate and oxygenation in order to support relevant use cases involving drug toxicity, efficacy testing, and organ-organ interaction.
Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus
Gabriel L. Hendricks,Kim L. Weirich,Karthik Viswanathan,Jing Li,Zachary Shriver,Joseph Ashour,Hidde L. Ploegh,Evelyn A. Kurt-Jones,Deborah Kuchnir Fygenson,Robert W. Finberg,James C. Comolli,Jennifer P. Wang +11 more
TL;DR: LSTc decoy liposomes prevent the spread of influenza virus during multiple rounds of replication in vitro and extend survival of mice challenged with a lethal dose of virus, indicating potential as a new therapeutic agent against emerging influenza strains.
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Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.
Gabriel L. Hendricks,Lourdes Velazquez,Serena T. Pham,Natasha Qaisar,James C. Delaney,Karthik Viswanathan,Leila N. Albers,James C. Comolli,Zachary Shriver,David M. Knipe,Evelyn A. Kurt-Jones,Deborah Kuchnir Fygenson,Jose M. Trevejo,Jennifer P. Wang,Robert W. Finberg +14 more
TL;DR: By targeting the well-conserved receptor-binding sites of HS-binding viruses, decoy liposomes functionalized with HS-octa are a promising therapeutic antiviral agent and illustrate the utility of the liposome delivery platform.
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Patent
Diagnosis and treatment of invasive aspergillosis
Sophia Koo,Horatio Rudulph Thomas,James C. Comolli,Preshious Rearden,Lindsey R. Baden,Francisco M. Marty +5 more
- 06 Sep 2013
TL;DR: In this article, methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described, which can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA.
6
Patent
Multivalent antiviral compositions, methods of making, and uses thereof
James C. Comolli,Robert W. Finberg,Deborah Kuchnir Fygenson,Zachary Shriver,Ram Sasisekharan,Jennifer P. Wang,Karthik Viswanathan +6 more
- 20 Oct 2014
TL;DR: In this article, the authors provide compositions, kits, and methods useful for treating or preventing viral infection, which comprise administering to a subject an effective amount of a sulfated polysaccharide composition.
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