James Brien
University of Western Ontario
8 Papers
189 Citations
James Brien is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Blood flow & Ingestion. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of James Brien include Queen's University & Lawson Health Research Institute.
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Papers
Effect of maternal ethanol ingestion on fetal breathing movements, gross body movements, and heart rate at 37 to 40 weeks' gestational age
William McLeod,William McLeod,James Brien,James Brien,Christopher Loomis,Christopher Loomis,Lesley Carmichael,Lesley Carmichael,Carol Probert,Carol Probert,John Patrick,John Patrick +11 more
TL;DR: The effect of maternal ingestion of ethanol on fetal breathing movements, gross fetal body movements, and fetal heart rate was studied in 11 healthy pregnant women at 37 to 40 weeks' gestation.
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Effects of maternal ethanol infusion on fetal cardiovascular and brain activity in lambs.
John Patrick,John Patrick,Bryan S. Richardson,Bryan S. Richardson,Greg Hasen,Greg Hasen,David W. Clarke,David W. Clarke,Mary E. Wlodek,Mary E. Wlodek,Jim Bousquet,Jim Bousquet,James Brien,James Brien +13 more
TL;DR: Ethanol was infused intravenously into chronically prepared pregnant ewes to support the hypothesis that ethanol suppresses fetal breathing movements by a direct central mechanism rather than indirectly by alteration of electrocortical activity.
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Increased uteroplacental production of prostaglandin-e2 during ethanol infusion
A. D. Bocking,K. R. Sinervo,Graeme N. Smith,Lesley Carmichael,John R. G. Challis,D. M. Olson,James Brien +6 more
TL;DR: The hypothesis that the placenta is the major source of the elevated fetal and maternal plasma PGE2 concentrations produced in pregnant sheep by maternal ethanol administration is supported.
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Disposition of acute, multiple-dose ethanol in the near-term pregnant ewe
James Brien,James Brien,David W. Clarke,David W. Clarke,Graeme N. Smith,Graeme N. Smith,Bryan S. Richardson,Bryan S. Richardson,John Patrick,John Patrick +9 more
TL;DR: The data indicate that for a binge-type drinking episode during near-term pregnancy, there is unimpeded bidirectional placental transfer of ethanol between the mother and the fetus; the amniotic fluid surrounding the fetus is a reservoir for ethanol in utero; elimination of ethanol from the maternal-fetal unit is regulated by maternal hepatic biotransformation of ethanol.
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Cerebral oxidative metabolism in fetal sheep with multiple-dose ethanol infusion.
TL;DR: A noted fall in fetal cerebral oxidative metabolism appears to be a direct depressant effect that was maximal at rather low fetal ethanol levels, which, if prolonged, might well affect cerebral growth and development.
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