James A. Marsh
Northwestern University
8 Papers
11 Citations
James A. Marsh is an academic researcher from Northwestern University. The author has contributed to research in topics: Cyclophilin & Saccharomyces cerevisiae. The author has an hindex of 7, co-authored 7 publications.
Chat about Author
Papers
Cns1 is an essential protein associated with the Hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Δ cells
TL;DR: The functional consequences of CNS1 overexpression and its physical association with the Hsp90 machinery indicate that Cns1 is a previously unidentified component of molecular chaperone complexes, which is the only tetratricopeptide repeat-containing component of Hsp 90 heterocomplexes found to be essential for cell viability under all conditions tested.
90
The Peptidyl-prolyl Isomerase Domain of the CyP-40 Cyclophilin Homolog Cpr7 Is Not Required to Support Growth or Glucocorticoid Receptor Activity in Saccharomyces cerevisiae*
Andrea A. Duina,James A. Marsh,Richard B. Kurtz,Hui Chen Jane Chang,Susan Lindquist,Richard F. Gaber +5 more
TL;DR: Results indicate that the TPR-containing carboxyl terminus of Cpr7 is sufficient for fundamental CPR7-dependent activity, and deletion of the entire PPIase domain did not significantly affect growth or Hsp90-mediated steroid receptor activity.
57
•Journal Article
Temporal Regulation of the Immune Response to LDH-C4 by an X-Linked Gene in C3H/HeJ and SJL/J Mice
TL;DR: The genetic control of the immune response to heterologous LDH-A and -B subunits has been studied in rabbits, rats, and inbred mice and reacts only with the isozymes containing the subunits used in immunization.
11
Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID
Patrick K. A. Kearns,Mihaly Badonyi,K. Lee,O. Fleming,L. Gerasimivicous,Sabrina Benton,J. Guy,Skot Neilson,Helen Wise,Scott A. Jenks,Kate Templeton,Christina Dold,Teresa Lambe,Alexander J. Mentzer,Jo Knight,A. Pollard,Combat,Madhvi Menon,Tracy Hussell,Circo,Laura McWhirter,Aliyah Carson,Rennos Fragkoudis,Stuart Rosser,David R. Cavanagh,James A. Marsh,Dirk A. Kleinjan,Nguepidjo Gilbert +27 more
TL;DR: This work identifies patterns of antibodies associated with immunopathology, including a non-isotype switching IgM response to a membrane protein epitope strongly associated with severe COVID-19 and suggests the mechanism is T independent B cell activation.