James A. Lederer
Brigham and Women's Hospital
168 Papers
1.4K Citations
James A. Lederer is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 49, co-authored 145 publications. Previous affiliations of James A. Lederer include University of Technology, Sydney & University of Wisconsin-Madison.
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Papers
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.
Fan Zhang,Kevin Wei,Kamil Slowikowski,Chamith Y. Fonseka,Deepak A. Rao,Stephen Kelly,Susan M. Goodman,Susan M. Goodman,Darren Tabechian,Laura B. Hughes,Karen Salomon-Escoto,Gerald F. Watts,A. Helena Jonsson,Javier Rangel-Moreno,Nida Meednu,Cristina Rozo,William Apruzzese,Thomas Eisenhaure,David J. Lieb,David L. Boyle,Arthur M. Mandelin,Brendan F. Boyce,Edward F. DiCarlo,Ellen M. Gravallese,Peter K. Gregersen,Larry W. Moreland,Gary S. Firestein,Nir Hacohen,Chad Nusbaum,James A. Lederer,Harris Perlman,Costantino Pitzalis,Andrew Filer,V. Michael Holers,Vivian P. Bykerk,Vivian P. Bykerk,Laura T. Donlin,Laura T. Donlin,Jennifer H. Anolik,Michael B. Brenner,Soumya Raychaudhuri +40 more
TL;DR: Several single-cell -omics approaches are used to define the cellular processes and pathways in the human RA joint and attributed IL6 expression to THY1+HLA-DRAhi fibroblasts and IL1B production to pro-inflammatory monocytes, potentially key mediators of RA pathogenesis.
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Deepak A. Rao,Michael F. Gurish,Jennifer L. Marshall,Kamil Slowikowski,Chamith Y. Fonseka,Yanyan Liu,Laura T. Donlin,Lauren A. Henderson,Kevin Wei,Fumitaka Mizoguchi,Nikola Teslovich,Nikola Teslovich,Michael E. Weinblatt,Elena Massarotti,Jonathan S. Coblyn,Simon M. Helfgott,Yvonne C. Lee,Derrick J. Todd,Vivian P. Bykerk,Susan M. Goodman,Susan M. Goodman,Alessandra B. Pernis,Lionel B. Ivashkiv,Elizabeth W. Karlson,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,James A. Lederer,Soumya Raychaudhuri,Michael B. Brenner +30 more
TL;DR: Using multidimensional cytometry, transcriptomics, and functional assays, a population of PD-1hiCXCR5− ‘peripheral helper’ T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF are defined.
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.
Ellen Shrock,Ellen Shrock,Eric Fujimura,Eric Fujimura,Tomasz Kula,Tomasz Kula,Richard T. Timms,Richard T. Timms,I-Hsiu Lee,Yumei Leng,Yumei Leng,Matthew L Robinson,Brandon M. Sie,Brandon M. Sie,Mamie Z. Li,Mamie Z. Li,Yuezhou Chen,Jennifer K. Logue,Adam Zuiani,Denise J. McCulloch,Felipe J.N. Lelis,Stephanie A. Henson,Daniel R. Monaco,Meghan Travers,Shaghayegh Habibi,William Clarke,Patrizio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Alicja Piechocka-Trocha,Jonathan Z. Li,Ashok Khatri,Helen Y. Chu,Alexandra-Chloé Villani,Kyle R. Kays,Marcia B. Goldberg,Nir Hacohen,Michael R. Filbin,Xu G. Yu,Bruce D. Walker,Bruce D. Walker,Duane R. Wesemann,H. Benjamin Larman,James A. Lederer,Stephen J. Elledge,Stephen J. Elledge +45 more
TL;DR: A systematic characterization of the humoral response to severe acute respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed, important for understanding the immunogenicity of the viral proteome and the basis for cross-reactivity with the common-cold coronaviruses.
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The immune cell landscape in kidneys of patients with lupus nephritis
Arnon Arazi,Deepak A. Rao,Celine C. Berthier,Anne Davidson,Yanyan Liu,Paul Hoover,Adam Chicoine,Thomas Eisenhaure,A. Helena Jonsson,Shuqiang Li,David J. Lieb,Fan Zhang,Kamil Slowikowski,Edward P. Browne,Akiko Noma,Danielle Sutherby,Scott Steelman,Dawn E. Smilek,Patti Tosta,William Apruzzese,Elena Massarotti,Maria Dall'Era,Meyeon Park,Diane L. Kamen,Richard A. Furie,Fernanda Payan-Schober,William F. Pendergraft,Elizabeth A. McInnis,Jill P. Buyon,Michelle Petri,Chaim Putterman,Kenneth C. Kalunian,E. Steve Woodle,James A. Lederer,David A. Hildeman,David A. Hildeman,Chad Nusbaum,Soumya Raychaudhuri,Matthias Kretzler,Jennifer H. Anolik,Michael B. Brenner,David Wofsy,Nir Hacohen,Betty Diamond +43 more
TL;DR: Analysis of kidney samples from patients with lupus nephritis and healthy control subjects revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses.
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
Fumitaka Mizoguchi,Kamil Slowikowski,Kevin Wei,Jennifer L. Marshall,Deepak A. Rao,Sook Kyung Chang,Hung N. Nguyen,Erika H. Noss,Erika H. Noss,Jason D. Turner,Brandon E. Earp,Philip E. Blazar,John Wright,Barry P. Simmons,Laura T. Donlin,George D. Kalliolias,Susan M. Goodman,Susan M. Goodman,Vivian P. Bykerk,Vivian P. Bykerk,Lionel B. Ivashkiv,Lionel B. Ivashkiv,James A. Lederer,Nir Hacohen,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,Soumya Raychaudhuri,Michael B. Brenner +29 more
TL;DR: Functional and transcriptional differences between fibroblast subsets from human synovial tissues are shown using bulk transcriptomics of targeted subpopulations and single-cell transcriptomics for rheumatoid arthritis.