James A. Hounshell
University of Virginia Health System
4 Papers
8 Citations
James A. Hounshell is an academic researcher from University of Virginia Health System. The author has contributed to research in topics: Protein subunit & Nociceptor. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of James A. Hounshell include University of Virginia.
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Papers
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
Aristos J. Alexandrou,Adam R. Brown,Mark L. Chapman,Mark Estacion,Jamie Turner,Malgorzata A. Mis,Anna Wilbrey,Elizabeth C. Payne,Alex Gutteridge,Peter J. Cox,Rachel Doyle,David Printzenhoff,Zhixin Lin,Brian E. Marron,Christopher William West,Nigel Alan Swain,R. Ian Storer,Stupple Paul Anthony,Neil A. Castle,James A. Hounshell,Mirko Rivara,Andrew D. Randall,Sulayman D. Dib-Hajj,Douglas S. Krafte,Stephen G. Waxman,Manoj K. Patel,Richard P. Butt,Edward B. Stevens +27 more
TL;DR: It is reported that Nav1.7 is the predominant functional TTX-sensitive Nav in mouse and human nociceptors and contributes to the initiation and the upstroke phase of the nOCiceptor action potential, and a role for Nav 1.7 in influencing synaptic transmission in the dorsal horn of the spinal cord as well as peripheral neuropeptide release in the skin is confirmed.
Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy.
Aradhya Nigam,Nicholas J. Hargus,Bryan S. Barker,Matteo Ottolini,James A. Hounshell,Edward H. Bertram,Edward Perez-Reyes,Manoj K. Patel +7 more
TL;DR: Findings support a role for T-type Ca2+ channel in establishing neuronal hyperexcitability of mEC layer II stellate neurons in TLE.
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CACHD1 is an α2δ-like protein that modulates CaV3 voltage-gated calcium channel activity
Graeme S. Cottrell,Camille H. Soubrane,James A. Hounshell,Hong Lin,Venetia Owenson,Michael Rigby,Peter J. Cox,Bryan S. Barker,Matteo Ottolini,Selvi Ince,Claudia C. Bauer,Edward Perez-Reyes,Manoj K. Patel,Edward B. Stevens,Gary J. Stephens +14 more
TL;DR: The data suggest that CACHD1 is structurally an α2δ-like protein that functionally modulates CaV3 voltage-gated calcium channel activity, a protein that regulates neuronal excitability and is a potential therapeutic target in conditions such as epilepsy and pain.
Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy
Jacy L. Wagnon,Bryan S. Barker,James A. Hounshell,Charlotte A. Haaxma,Amy Shealy,Timothy J. Moss,Sumit Parikh,Ricka D. Messer,Manoj K. Patel,Miriam H. Meisler +9 more
TL;DR: The early infantile epileptic encephalopathy type 13 (EIEE13, OMIM #614558) results from de novo missense mutations of SCN8A encoding the voltage‐gated sodium channel Nav1.6.