Preparation, Evaluation, and Histopathological Studies of Ondansetron-Loaded Invasomes Transdermal Gel

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

Objective: The objective of the research was the preparation and evaluation of methotrexate nanoemulsion to improve its solubility, permeability, and bioavailability. Methods: The formulation components were selected based on the solubility study, and the pseudo-ternary phase diagrams were constructed by the aqueous phase titration method. Result and discussion: The prepared nanoemulsions were exposed to several thermodynamic stability studies and then to many characterizations tests for the selection of the best formulation. F 11 is the best formula since it has a 57 nm globule size, 0.21 polydispersity index, +23.67 zeta potential, and 99.57% light transmittance. FTIR study confirmed no incompatibility between drug and excipients. Conclusion: F 11 was a promising nanoemulsion formula that improved methotrexate permeability and bioavailability.

/pdf/formulation-and-in-vitro-evaluation-of-methotrexate-13vsaze4.pdf

Formulation and In-vitro Evaluation of Methotrexate Nanoemulsion using Natural Oil

ABSTRACT: In order to study the existing information about the positive uses of essential oils (EOs) in treating arthritis, this review gives an overview of how natural essential oils, which have various characteristics like natural occurrence, commending penetration ability and partitioning action into skin, are used in the treatment of arthritis, also which can help various drugs penetrate the skin more effectively for the same. While reviewing various scientific experiments, we found that various oils were used alone or in combination, in different ways/methods on patients suffering from arthritis or on animals induced with arthritis (in-vivo study) & the results were quiet positive & effective in treating types of arthritis. As a result of our scientific literature survey, we found number of studies evaluating potential anti-arthritic activity of EOs and their major constituents has increased giving hope to an interesting new therapeutic applications of EOs in the future.

Review on Essential Oils and Ways to Use Them for the Treatment of Arthritis

Abstract 
Objective: the idea of this study to improve transdermal permeability of Methotrexate using eucalyptus oil, olive oil and peppermint oil as enhancers.Method: eucalyptus oil (2% and 4%), peppermint oil (2% and 4%) and olive oil (2% and 4%) all used as natural enhancers to develop transdermal permeability of Methotrexate via gel formulation. The gel was subjected to many physiochemical properties tests. In-vitro release and permeability studies for the drug were done by Franz cell diffusion across synthetic membrane, kinetic model was studied via korsmeyer- peppas equation.Result: the results demonstrate that safe, nonirritant or cause necrosis to rats' skin and stable till 60 days gel was successfully formulated.Methotrexate penetration alone without enhancer is only about 20%, while using enhancers reach to 85%, 99% and 90% with eucalyptus oil 4%, peppermint oil 4% and olive oil 4% respectively after 24 hours.Conclusion: Methotrexate transdermal gel was prepared and evaluated fruitfully in-vitro with a good permeation across semipermeable membrane. The results indicated that using of peppermint oil as enhancer have superiority to enhance the transdermal permeation of the Methotrexate.

/pdf/permeability-enhancement-of-methotrexate-transdermal-gel-35etffb1.pdf

Permeability Enhancement of Methotrexate Transdermal Gel using Eucalyptus oil, Peppermint Oil and Olive Oil(Conference Paper )#

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Jamal Ali Ashoor

Author Tools

Chat about Author

Papers

Permeability Enhancement of Methotrexate Transdermal Gel using Eucalyptus oil, Peppermint Oil and Olive Oil(Conference Paper )#