Jakob Seidlitz
University of Pennsylvania
140 Papers
163 Citations
Jakob Seidlitz is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 21, co-authored 99 publications. Previous affiliations of Jakob Seidlitz include National Institutes of Health & University of Cambridge.
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Papers
Microstructural and functional gradients are increasingly dissociated in transmodal cortices
Casey Paquola,Reinder Vos de Wael,Konrad Wagstyl,Richard A. I. Bethlehem,Seok-Jun Hong,Jakob Seidlitz,Edward T. Bullmore,Alan C. Evans,Alan C. Evans,Bratislav Misic,Daniel S. Margulies,Jonathan Smallwood,Boris C. Bernhardt +12 more
TL;DR: These findings demonstrate a relative decoupling of macroscale functional from microstructural gradients in transmodal regions, which likely contributes to the flexible role these regions play in human cognition.
Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology.
Valerie J. Sydnor,Bart Larsen,Danielle S. Bassett,Aaron Alexander-Bloch,Aaron Alexander-Bloch,Damien A. Fair,Conor Liston,Allyson P. Mackey,Michael P. Milham,Michael P. Milham,Adam Pines,David R. Roalf,Jakob Seidlitz,Jakob Seidlitz,Ting Xu,Armin Raznahan,Theodore D. Satterthwaite +16 more
TL;DR: The human brain undergoes a prolonged period of cortical development that spans multiple decades, conforming to an evolutionarily rooted, sensorimotor-to-association axis of cortical organization as discussed by the authors.
453
Morphometric Similarity Networks Detect Microscale Cortical Organization and Predict Inter-Individual Cognitive Variation
Jakob Seidlitz,Jakob Seidlitz,František Váša,Maxwell Shinn,Rafael Romero-Garcia,Kirstie Whitaker,Petra E. Vértes,Konrad Wagstyl,Paul K. Reardon,Liv S. Clasen,Siyuan Liu,Adam Messinger,David A. Leopold,Peter Fonagy,Raymond J. Dolan,Peter B. Jones,Ian M. Goodyer,Armin Raznahan,Edward T. Bullmore +18 more
TL;DR: A new technique for cortical network mapping based on inter-regional similarity of multiple morphometric parameters measured using multimodal MRI is introduced, finding that the resulting morphometric similarity networks (MSNs) have a complex topological organization comprising modules and high-degree hubs.
434
Adolescent Tuning of Association Cortex in Human Structural Brain Networks.
František Váša,Jakob Seidlitz,Jakob Seidlitz,Rafael Romero-Garcia,Kirstie Whitaker,Kirstie Whitaker,Gideon Rosenthal,Petra E. Vértes,Maxwell Shinn,Aaron Alexander-Bloch,Peter Fonagy,Raymond J. Dolan,Raymond J. Dolan,Peter B. Jones,Ian M. Goodyer,Olaf Sporns,Edward T. Bullmore,Edward T. Bullmore +17 more
TL;DR: It is concluded that human adolescence is associated with biologically plausible changes in structural imaging markers of brain network organization, consistent with the concept of tuning or consolidating anatomical connectivity between frontal cortex and the rest of the connectome.
Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes.
Sarah E. Morgan,Jakob Seidlitz,Jakob Seidlitz,Kirstie Whitaker,Kirstie Whitaker,Rafael Romero-Garcia,Nicholas E. Clifton,Cristina Scarpazza,Cristina Scarpazza,Therese van Amelsvoort,Machteld Marcelis,Jim van Os,Jim van Os,Jim van Os,Gary Donohoe,David Mothersill,Aiden Corvin,Andrew Pocklington,Armin Raznahan,Philip McGuire,Petra E. Vértes,Petra E. Vértes,Petra E. Vértes,Edward T. Bullmore,Edward T. Bullmore +24 more
TL;DR: It is proposed that this combined analysis of neuroimaging and transcriptional data provides insight into how previously implicated genes and proteins as well as a number of unreported genes in their topological vicinity on the protein interaction network may drive structural brain network changes mediating the genetic risk of schizophrenia.
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