Jake Ormond
University of Toronto
7 Papers
Jake Ormond is an academic researcher from University of Toronto. The author has contributed to research in topics: Inhibitory postsynaptic potential & Excitatory postsynaptic potential. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Jake Ormond include University of Lethbridge & RIKEN Brain Science Institute.
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Papers
Hippocampal place cells have goal-oriented vector fields during navigation
Jake Ormond,John O'Keefe +1 more
TL;DR: In this article , the authors show that the hippocampus creates a vector-based model to support flexible navigation, allowing animals to select optimal paths to destinations from any location in the environment, and that the distribution of these convergence sinks (ConSinks) was centred near the goal location and the population vector field converged on the goal, providing a strong navigational signal.
Neto2 is a KCC2 interacting protein required for neuronal Cl− regulation in hippocampal neurons
Evgueni A. Ivakine,Brooke A. Acton,Vivek Mahadevan,Jake Ormond,Man Tang,Jessica C. Pressey,Michelle Y. Huang,David Ng,Eric Delpire,Michael W. Salter,Melanie A. Woodin,Roderick R. McInnes +11 more
TL;DR: KCC2 is critically regulated by the single-pass transmembrane protein neuropilin and tolloid like-2 (Neto2), which is required to maintain the normal abundance of KCC2 and specifically associates with the active oligomeric form of the transporter.
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Disinhibition mediates a form of hippocampal long-term potentiation in area CA1.
Jake Ormond,Melanie A. Woodin +1 more
TL;DR: Disinhibition-mediated LTP requires NMDAR activation, suggesting a role in types of learning and memory attributed primarily to the former and raising the possibility of a previously unrecognized target for therapeutic intervention in disorders linked to memory deficits, as well as a potentially overlooked site of LTP expression in other areas of the brain.
Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific.
TL;DR: It is found that the underlying depolarization of EGABA is not restricted to the paired pathway, but rather is expressed to the same extent at unpaired control pathways, and the overall strength of GABAergic transmission is maintained at the unpaired pathway by a heterosynaptic increase in GABAergic conductance.
Enhanced Reactivation of Remapping Place Cells during Aversive Learning
TL;DR: In this paper , the authors developed a spatial decision-making task in which male rats learned to navigate a multi-arm maze to a goal location for food reward while avoiding maze arms in which aversive stimuli were delivered.