Jairo Rodriguez
Fred Hutchinson Cancer Research Center
7 Papers
86 Citations
Jairo Rodriguez is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Origin recognition complex & Control of chromosome duplication. The author has an hindex of 6, co-authored 7 publications.
Chat about Author
Papers
Nucleosome occupancy as a novel chromatin parameter for replication origin functions
TL;DR: It is demonstrated that nucleosome occupancy around origins in G1 is established during transition from G2/M to G1 in a pre-RC-dependent manner and is associated with an abnormal global origin usage profile, suggesting that proper establishment of nucleosomes occupancyaround origins is a critical step for regulation of global origin activities.
ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress
Jairo Rodriguez,Toshio Tsukiyama +1 more
TL;DR: A novel genome-wide method to measure chromatin accessibility to micrococcal nuclease (MNase) that is normalized for nucleosome density is developed, and it is found that Mec1, a key regulatory ATR-like kinase in the S-phase checkpoint, is required for both normal Chromatin accessibility around replication forks and replication fork rate during replication stress.
Initiation of DNA Replication from Non-Canonical Sites on an Origin-Depleted Chromosome
TL;DR: Replication profiling of S. cerevisiae chromosome III showed that DNA replication initiates from non-canonical loci around deleted origins in yeast, suggesting that replication initiation can be unexpectedly flexible in this organism.
25
Chromatin Remodeling Factors Isw2 and Ino80 Regulate Checkpoint Activity and Chromatin Structure in S Phase
TL;DR: This study found that Isw2 and Ino80 have a more pronounced role in attenuating checkpoint activity during late S phase in the presence of methyl methanesulfonate (MMS), and proposes a novel mechanism to attenuate S-phase checkpoint activity through a novel mechanisms.
24
ISWI Chromatin Remodeling Complexes
Toshio Tsukiyama,Naomi L. Bogenschutz,Tracey J Kwong,Jairo Rodriguez,Ashwin Unnikrishnan,Adam N. Yadon +5 more
- 01 Jan 2010
TL;DR: Because ISWI complexes are involved in a diverse array of DNA dependent processes, elucidating the mechanisms of ISWI functions significantly increases the understanding of these essential biological processes.
2