Molecular self-assembly is the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds. Molecular self-assembly is ubiquitous in biological systems and underlies the formation of a wide variety of complex biological structures. Understanding self-assembly and the associated noncovalent interactions that connect complementary interacting molecular surfaces in biological aggregates is a central concern in structural biochemistry. Self-assembly is also emerging as a new strategy in chemical synthesis, with the potential of generating nonbiological structures with dimensions of 1 to 10(2) nanometers (with molecular weights of 10(4) to 10(10) daltons). Structures in the upper part of this range of sizes are presently inaccessible through chemical synthesis, and the ability to prepare them would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.

Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures

Increasing customer demand for durable and functional apparel manufactured in a sustainable manner has created an opportunity for nanomaterials to be integrated into textile substrates. Nanomoieties can induce stain repellence, wrinkle-freeness, static elimination, and electrical conductivity to fibers without compromising their comfort and flexibility. Nanomaterials also offer a wider application potential to create connected garments that can sense and respond to external stimuli via electrical, color, or physiological signals. This review discusses electronic and photonic nanotechnologies that are integrated with textiles and shows their applications in displays, sensing, and drug release within the context of performance, durability, and connectivity. Risk factors including nanotoxicity, nanomaterial release during washing, and environmental impact of nanotextiles based on life cycle assessments have been evaluated. This review also provides an analysis of nanotechnology consolidation in the textiles ...

/pdf/nanotechnology-in-textiles-31w22yxxky.pdf

Nanotechnology in Textiles

Bio-inspired nano-materials can be formed by the ordered assembly of elementary building blocks using recognition modules and structural elements. Among the biological sources, peptides and proteins are of special interest due to their role as major structural elements in all living systems, ranging from bacteria to humans in a continuum of magnitudes, from the nano-scale to the macro-scale. Peptides, as short as dipeptides, contain all the molecular information needed to form well-ordered structures at the nano-scale. Here, in light of the significant advancements in the field of peptide nanostructures in the last few years, we provide an updated overview of this subject. The use of these nanostructures was indeed recently demonstrated in various fields including the design of molecular motors based on nanostructure complexation with a metal-organic framework, the delivery of therapeutic agents, the development of energy storage devices and the fabrication of piezoelectric-based sensors.

/pdf/the-physical-properties-of-supramolecular-peptide-assemblies-47az72fo3t.pdf

The physical properties of supramolecular peptide assemblies: from building block association to technological applications.

Contact lenses as a minimally invasive platform for diagnostics and drug delivery have emerged in recent years. Contact lens sensors have been developed for analyzing the glucose composition of tears as a surrogate for blood glucose monitoring and for the diagnosis of glaucoma by measuring intraocular pressure. However, the eye offers a wider diagnostic potential as a sensing site and therefore contact lens sensors have the potential to improve the diagnosis and treatment of many diseases and conditions. With advances in polymer synthesis, electronics and micro/nanofabrication, contact lens sensors can be produced to quantify the concentrations of many biomolecules in ocular fluids. Non- or minimally invasive contact lens sensors can be used directly in a clinical or point-of-care setting to monitor a disease state continuously. This article reviews the state-of-the-art in contact lens sensor fabrication, their detection, wireless powering, and readout mechanisms, and integration with mobile devices and smartphones. High-volume manufacturing considerations of contact lenses are also covered and a case study of an intraocular pressure contact lens sensor is provided as an example of a successful product. This Review further analyzes the contact lens market and the FDA regulatory requirements for commercialization of contact lens sensors.

/pdf/contact-lens-sensors-in-ocular-diagnostics-3cjapb8hja.pdf

Contact Lens Sensors in Ocular Diagnostics

pdf/review-on-microfluidic-paper-based-analytical-devices-3b0hjwo7ff.pdf

Review on microfluidic paper-based analytical devices towards commercialisation.

https://www.researchgate.net/file.PostFileLoader.html?id=55c2f19860614bf8408b45d5&assetKey=AS%3A273670520410114%401442259544828

Gold cleaning methods for electrochemical detection applications

Lab-on-a-chip devices and micro-total analysis systems: a practical guide

Self-assembled amyloid peptide nanotubes (SAPNT) were manipulated and immobilized using dielectrophoresis. Micro-patterned electrodes of Au were fabricated by photolithography and lifted off on a silicon dioxide layer. SAPNT were manipulated by adjusting the amplitude and frequency of the applied voltage. The immobilized SAPNT were evaluated by SEM and atomic force microscopy. The conductivity of the immobilized SAPNT was studied by I-V characterization, for both single SAPNT and bundles. This work illustrates a way to manipulate and integrate biological nanostructures into novel bio-nanoassemblies with concrete applications, such as field-effect transistors, microprobes, microarrays, and biosensing devices.

Manipulation of self-assembly amyloid peptide nanotubes by dielectrophoresis.

Biological self-assembled structures are receiving increasing focus within micro- and nanotechnology, for example, as sensing devices, due to the fact that they are cheap to produce and easy to functionalize. Therefore, methods for the characterization of these structures are much needed. In this paper, electrostatic force microscopy (EFM) was used to distinguish between hollow nanotubes formed by self-assembly by a simple aromatic dipeptide, L-phenylalanine, silver-filled peptide-based nanotubes, and silver wires placed on prefabricated SiO2 surfaces with a backgate. The investigation shows that it is possible to distinguish between these three types of structures using this method. Further, an agreement between the detected signal and the structure of the hollow peptide was demonstrated; however only qualitative agreement with the mathematical expressing of the tubes is shown.

Qualitative mapping of structurally different dipeptide nanotubes.

Thestudyoftheinteractionsoffolicacid(FA)withsurfaceenhancedRamanscatteringsubstratesisrelevantforunderstandingitsadsorptionmechanismandforfabricatinganalyticaldevicesfordetectionofmalignantcellsover-expressingfolatereceptors.ThispaperpresentsastudyoftheadsorptionofFAonsilver-cappedsiliconnanopillarsubstratesemployingsurfaceenhancedRamanscattering spectroscopy and density functional theory calculations. The experimentally observed vibrations from free FA and FAbound to the Ag surface display different vibrational spectra indicating chemical interaction of the molecule with the metal sur-face.Density functionaltheorycalculations showthatthe Ag–FAinteractionisprimarily through the nitrogenfromthe pteridinering anchoring tothe Agmetal surface. Toinvestigatethe Ag–FAbindingbehaviorfurther, the adsorptionisotherm ofFAonthesilver-capped silicon nanopillar surface is estimated. The results show a positive cooperative Ag–FA binding mechanism. That is,adsorbed FA increases the affinity of new incoming FA molecules. Copyright © 2015 John Wiley & Sons, Ltd.Additional supporting information may be found in the online version of this article at the publisher’s web site.Keywords: SERS; nanopillar; silver; folic acid; adsorption isotherm

Silver‐capped silicon nanopillar platforms for adsorption studies of folic acid using surface enhanced Raman spectroscopy and density functional theory

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