Jaejoon Won
KAIST
12 Papers
192 Citations
Jaejoon Won is an academic researcher from KAIST. The author has contributed to research in topics: Wnt signaling pathway & Chromatin immunoprecipitation. The author has an hindex of 10, co-authored 12 publications.
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Papers
A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells
TL;DR: In this article, magnetism-based interaction capture (MAGIC) was used to identify molecular targets on the basis of induced movement of superparamagnetic nanoparticles inside living cells.
157
Protein-kinase-C-mediated β-catenin phosphorylation negatively regulates the Wnt/β-catenin pathway
Jungsug Gwak,Munju Cho,Soo-Jung Gong,Jaejoon Won,Dong-Eun Kim,Eun Young Kim,Sang Sup Lee,Mina Kim,Tae Kook Kim,Jae-Gook Shin,Sangtaek Oh +10 more
TL;DR: Small-molecule-based identification of protein kinase C (PKC)-mediated β-catenin phosphorylation as a novel mechanism regulating the Wnt/β- catenin pathway is presented and it is suggested that the PKC pathway negatively regulates the β-Catenin level outside of the Wnnt/ β-catsin pathway.
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Small molecule–based reversible reprogramming of cellular lifespan
Jaejoon Won,Mina Kim,Nuri Kim,Jin Hee Ahn,Woo Gil Lee,Sungsoo Kim,Ki Young Chang,Yong Weon Yi,Tae Kook Kim,Tae Kook Kim +9 more
TL;DR: It is shown that the intrinsic 'senescence clock' can be reset in a reversible manner by selective modulation of the ataxia telangiectasia–mutated (ATM) protein and ATM- and Rad3-related (ATR) protein with a small molecule, CGK733.
72
Diclofenac attenuates Wnt/β‐catenin signaling in colon cancer cells by activation of NF‐κB
Munju Cho,Jungsug Gwak,Seoyoung Park,Jaejoon Won,Dong-Eun Kim,Sung Su Yea,In-June Cha,Tae Kook Kim,Jae-Gook Shin,Sangtaek Oh +9 more
TL;DR: Diclofenac inhibits Wnt/β‐catenin signaling via the activation of NF‐κB in colon cancer cells and reduces the expression of β‐ catenin/TCF‐dependent genes.
62
Small-molecule-based identification of dynamic assembly of E2F–pocket protein–histone deacetylase complex for telomerase regulation in human cells
TL;DR: This work shows the small-molecule-based identification of the assembly and disassembly of E2F-pocket protein-histone deacetylase (HDAC) complex as a key mechanistic basis for the repression and activation of hTERT in normal human cells.
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