JaeJoon Sim
Toho University
5 Papers
145 Citations
JaeJoon Sim is an academic researcher from Toho University. The author has contributed to research in topics: Asthma & Basement membrane. The author has an hindex of 5, co-authored 5 publications.
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Papers
Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma.
TL;DR: It is suggested that corticosteroid treatment of asthma can reduce subepithelial collagen deposition by downregulation of MMP-9 expression and upregulation of TIMP-1 expression.
230
Inhaled corticosteroid reduced lamina reticularis of the basement membrane by modulation of insulin‐like growth factor (IGF)‐I expression in bronchial asthma
Makoto Hoshino,Yutaka Nakamura,JaeJoon Sim,Yoshihiro Yamashiro,Kou Uchida,Kimio Hosaka,Isogai S +6 more
TL;DR: Pathological studies of bronchial biopsy specimens have confirmed the apparent thickening of lamina reticularis of the epithelial basement membrane in patients treated with corticosteroid treatment.
143
Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthma
TL;DR: The effect of inhaled corticosteroids on increased airway mucosal vascularity in asthmatics has been little studied.
92
Effect of AA-2414, a thromboxane A2 receptor antagonist, on airway inflammation in subjects with asthma
TL;DR: It is suggested that AA-2414 treatment of patients with asthma may inhibit activated eosinophil infiltration in part by modulating the expression of chemokines in bronchial tissues.
58
Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation
TL;DR: It is suggested that collagen III, collagen V, and tenascin deposition in basement membrane in subjects with bronchial asthma are associated with increased expression of MMP-9, which may be produced by eosinophils, and that airway remodeling in Subjects with asthma may be related to air-flow obstruction and airway hyperresponsiveness.