Jae Chan Ryu
Yonsei University
6 Papers
Jae Chan Ryu is an academic researcher from Yonsei University. The author has contributed to research in topics: Dual oxidase 2 & NADPH oxidase. The author has an hindex of 6, co-authored 6 publications.
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Papers
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages
Min-Ji Kim,Soo Han Bae,Jae Chan Ryu,Younghee Kwon,Ji Hwan Oh,Jeongho Kwon,Jong Seok Moon,Kyubo Kim,Atsushi Miyawaki,Min Goo Lee,Jaekyoon Shin,Young Sam Kim,Chang Hoon Kim,Stefan W. Ryter,Augustine M.K. Choi,Sue Goo Rhee,Ji-Hwan Ryu,Joo Heon Yoon +17 more
TL;DR: It is demonstrated that SESN2 (sestrin 2), known as stress-inducible protein, suppresses prolonged NLRP3 inflammasome activation by clearance of damaged mitochondria through inducing mitophagy in macrophages, defining a unique regulatory mechanism of mitophagic activation for immunological homeostasis that protects the host from sepsis.
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Synthesis of a highly HOCl-selective fluorescent probe and its use for imaging HOCl in cells and organisms
Xiaoqiang Chen,Xiaoqiang Chen,Kyung Ah Lee,Xintong Ren,Jae Chan Ryu,Gyungmi Kim,Ji-Hwan Ryu,Won-Jae Lee,Juyoung Yoon +8 more
TL;DR: In this article, the authors outline protocols for the preparation of a rhodamine-based HOCl probe, as well as applications thereof, with which to detect HOCl in living cells and organisms.
169
A Far-Red-Emitting Fluorescence Probe for Sensitive and Selective Detection of Peroxynitrite in Live Cells and Tissues.
TL;DR: The far-red-emitting fluorescence probe 1, containing a rhodamine derivative and a hydrazide reactive group, was developed for peroxynitrite detection and imaging and was successfully utilized to detect exogenous and endogenous peroxlynitrite in HeLa and RAW 264.7 cells.
133
Distinct TLR-mediated pathways regulate house dust mite–induced allergic disease in the upper and lower airways
Ji-Hwan Ryu,Jung Yeon Yoo,Min-Ji Kim,Sang Gyu Hwang,Kwang Chul Ahn,Jae Chan Ryu,Mi Kyung Choi,Jung Hee Joo,Chang Hoon Kim,Sang Nam Lee,Won-Jae Lee,Jaesang Kim,Dong Min Shin,Mi-Na Kweon,Yun Soo Bae,Joo-Heon Yoon +15 more
TL;DR: A novel finding of distinctive innate immunity of the nose and lungs, respectively, which trigger AR and AA is described, by showing the critical role of HDM-induced TLR activation via dual oxidase 2-mediated reactive oxygen species.
Dual Oxidase 2 in Lung Epithelia Is Essential for Hyperoxia-Induced Acute Lung Injury in Mice
TL;DR: It is shown that dual oxidase 2 (DUOX2) is a key NOX enzyme that affects hyperoxia-induced ROS production, particularly in type II AECs, leading to lung injury.