Jacques R. Fresco
Princeton University
97 Papers
2.5K Citations
Jacques R. Fresco is an academic researcher from Princeton University. The author has contributed to research in topics: Base pair & Helix. The author has an hindex of 37, co-authored 97 publications.
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Papers
Structural and energetic consequences of noncomplementary base oppositions in nucleic acid helices.
A.J. Lomant,Jacques R. Fresco +1 more
TL;DR: In the chapter, the variety of codon-anticodon interactions observed in protein synthesis suggests that there can be some flexibility in these requirements, such that pairing need not be restricted to base oppositions that are precisely accommodated by the one-dimensional lattice of a long double helix.
91
Increased Frequency of Cysteine, Tyrosine, and Phenylalanine Residues Since the Last Universal Ancestor
Dawn J. Brooks,Jacques R. Fresco +1 more
TL;DR: Evidence is presented here that cysteine, tyrosine, and phenylalanine residues have substantially increased in frequency since the three primary lineages diverged more than three billion years ago, suggesting their late introduction into the genetic code.
87
Nucleotide sequence of the "denaturable" leucine transfer RNA from yeast.
TL;DR: The nucleotide sequence of " denaturable"leucine acceptor transfer RNA from baker's yeast was determined on 32P-labeled material and the basis on which the sequence was deduced from the products of complete enzymatic digestion is presented.
73
UV spectroscopic identification and thermodynamic analysis of protonated third strand deoxycytidine residues at neutrality in the triplex d(C+-T)6:[d(A-G)6d(C−-T)6]; evidence for a proton switch
TL;DR: This work shows that when third strand binding requires protonated residues that would otherwise be neutral, triplex formation and dissociation are mediated by proton uptake and release, i.e., a proton switch.