Jacques Grill
Institut Gustave Roussy
326 Papers
1.3K Citations
Jacques Grill is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Medicine & Glioma. The author has an hindex of 61, co-authored 282 publications. Previous affiliations of Jacques Grill include University of Paris-Sud & VU University Amsterdam.
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Papers
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
Alan Mackay,Anna Burford,Diana Carvalho,Elisa Izquierdo,Janat Fazal-Salom,Kathryn R. Taylor,Kathryn R. Taylor,Lynn Bjerke,Matthew Clarke,Mara Vinci,Meera Nandhabalan,Sara Temelso,Sergey Popov,Sergey Popov,Valeria Molinari,Pichai Raman,Angela J. Waanders,Harry J. Han,Saumya Gupta,Lynley V. Marshall,Stergios Zacharoulis,Sucheta Vaidya,Henry Mandeville,Leslie R. Bridges,Andrew J. Martin,Safa Al-Sarraj,Christopher Chandler,Ho Keung Ng,Xingang Li,Kun Mu,Saoussen Trabelsi,Dorra H'mida-Ben Brahim,Alexei N. Kisljakov,Dmitry M. Konovalov,Andrew S. Moore,Angel M. Carcaboso,Mariona Suñol,Carmen Torres,Ofelia Cruz,Jaume Mora,Ludmila I. Shats,João Norberto Stávale,Lucas Tadeu Bidinotto,Rui Manuel Reis,Natacha Entz-Werle,Michael A. Farrell,Jane Cryan,Darach Crimmins,John Caird,Jane Pears,Michelle Monje,Marie-Anne Debily,David Castel,Jacques Grill,Cynthia Hawkins,Hamid Nikbakht,Nada Jabado,Suzanne J. Baker,Stefan M. Pfister,Stefan M. Pfister,David T.W. Jones,Maryam Fouladi,André O. von Bueren,André O. von Bueren,Michael Baudis,Adam C. Resnick,Chris Jones +66 more
TL;DR: Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct, and co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H 3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H2.1K 27M are identified.
1K
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Dominik Sturm,Dominik Sturm,Brent A. Orr,Umut H. Toprak,Volker Hovestadt,David T.W. Jones,David Capper,David Capper,Martin Sill,Ivo Buchhalter,Paul A. Northcott,Irina Leis,Marina Ryzhova,Christian Koelsche,Christian Koelsche,Elke Pfaff,Elke Pfaff,Sariah Allen,Gnanaprakash Balasubramanian,Barbara C. Worst,Barbara C. Worst,Kristian W. Pajtler,Sebastian Brabetz,Pascal Johann,Pascal Johann,Felix Sahm,Felix Sahm,Jüri Reimand,Jüri Reimand,Alan Mackay,Diana Carvalho,Marc Remke,Joanna J. Phillips,Arie Perry,Cynthia Cowdrey,Rachid Drissi,Maryam Fouladi,Felice Giangaspero,Maria Łastowska,Wiesława Grajkowska,Wolfram Scheurlen,Torsten Pietsch,Christian Hagel,Johannes Gojo,Daniela Lötsch,Walter Berger,Irene Slavc,Christine Haberler,Anne Jouvet,Stefan Holm,Silvia Hofer,Marco Prinz,Catherine Keohane,Iris Fried,Christian Mawrin,David Scheie,Bret C. Mobley,Matthew Schniederjan,Mariarita Santi,Anna Maria Buccoliero,Sonika Dahiya,Christof M. Kramm,André O. von Bueren,Katja von Hoff,Stefan Rutkowski,Christel Herold-Mende,Michael C. Frühwald,Till Milde,Till Milde,Martin Hasselblatt,Pieter Wesseling,Pieter Wesseling,Jochen Rößler,Ulrich Schüller,Martin Ebinger,Jens Schittenhelm,Stephan Frank,Rainer Grobholz,Istvan Vajtai,Volkmar Hans,Reinhard Schneppenheim,Karel Zitterbart,V. Peter Collins,Eleonora Aronica,Pascale Varlet,Stéphanie Puget,Christelle Dufour,Jacques Grill,Dominique Figarella-Branger,Marietta Wolter,Martin U. Schuhmann,Tarek Shalaby,Michael A. Grotzer,Timothy E. Van Meter,Camelia M. Monoranu,Jörg Felsberg,Guido Reifenberger,Matija Snuderl,Lynn Ann Forrester,Jan Koster,Rogier Versteeg,Richard Volckmann,Peter van Sluis,Stephan Wolf,Tom Mikkelsen,Amar Gajjar,Kenneth Aldape,Andrew S. Moore,Michael D. Taylor,Chris Jones,Nada Jabado,Matthias A. Karajannis,Roland Eils,Matthias Schlesner,Peter Lichter,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister,David W. Ellison,Andrey Korshunov,Andrey Korshunov,Marcel Kool +122 more
TL;DR: It is demonstrated that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors.
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Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
Sebastian Bender,Sebastian Bender,Yujie Tang,Anders Lindroth,Volker Hovestadt,David T.W. Jones,Marcel Kool,Marc Zapatka,Paul A. Northcott,Dominik Sturm,Wei Wang,Bernhard Radlwimmer,Jonas W. Højfeldt,Nathalene Truffaux,David Castel,Simone Schubert,Marina Ryzhova,Huriye Seker-Cin,Jan Gronych,Pascal-David Johann,Pascal-David Johann,Sebastian Stark,Sebastian Stark,Jochen Meyer,Jochen Meyer,Till Milde,Till Milde,Martin U. Schuhmann,Martin Ebinger,Camelia M. Monoranu,Anitha Ponnuswami,S. Chen,Chris Jones,Olaf Witt,Olaf Witt,V. Peter Collins,Andreas von Deimling,Andreas von Deimling,Nada Jabado,Stéphanie Puget,Jacques Grill,Kristian Helin,Andrey Korshunov,Andrey Korshunov,Peter Lichter,Michelle Monje,Christoph Plass,Yoon Jae Cho,Stefan M. Pfister,Stefan M. Pfister +49 more
TL;DR: It is shown that reduced H3K27me3 levels and DNA hypomethylation act in concert to activate gene expression in K27M mutant pHGGs, and it is demonstrated that this is caused by aberrant recruitment of the PRC2 complex to K 27M mutant H3.3.
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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
Catherine S. Grasso,Yujie Tang,Yujie Tang,Nathalene Truffaux,Noah E. Berlow,Lining Liu,Marie-Anne Debily,Marie-Anne Debily,Michael J. Quist,Lara E. Davis,Elaine C. Huang,Pamelyn Woo,Anitha Ponnuswami,S. Chen,Tessa Johung,Wenchao Sun,Mari Kogiso,Yuchen Du,Lin Qi,Yulun Huang,Yulun Huang,Marianne Hütt-Cabezas,Katherine E. Warren,Ludivine Le Dret,Paul S. Meltzer,Hua Mao,Martha Quezado,Dannis G. van Vuurden,Jinu Abraham,Maryam Fouladi,Matthew N. Svalina,Nicholas J. Wang,Cynthia Hawkins,Javad Nazarian,Marta M. Alonso,Eric H. Raabe,Esther Hulleman,Paul T. Spellman,Xiao-Nan Li,Charles Keller,Ranadip Pal,Jacques Grill,Jacques Grill,Michelle Monje +43 more
TL;DR: Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects, and these data suggest a promising therapeutic strategy for DIPG.
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.
David Castel,Cathy Philippe,Raphael Calmon,Ludivine Le Dret,Nathalene Truffaux,Nathalie Boddaert,Mélanie Pagès,Kathryn R. Taylor,Patrick Saulnier,Ludovic Lacroix,Alan Mackay,Chris Jones,Christian Sainte-Rose,Thomas Blauwblomme,Felipe Andreiuolo,Stéphanie Puget,Jacques Grill,Pascale Varlet,Marie-Anne Debily,Marie-Anne Debily +19 more
TL;DR: H3K27 alterations appear as the founding event in DIPG and the mutations in the two main histone H3 variants drive two distinct oncogenic programmes with potential specific therapeutic targets.