Jacques Duhault
44 Papers
508 Citations
Jacques Duhault is an academic researcher. The author has contributed to research in topics: Receptor & Hyperpolarization (biology). The author has an hindex of 16, co-authored 44 publications.
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Papers
Acetylcholine‐induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice
Thierry Chataigneau,Michel Félétou,Paul L. Huang,Mark C. Fishman,Jacques Duhault,Paul M. Vanhoutte +5 more
TL;DR: It is demonstrated that in the blood vessels studied, the endothelium‐dependent relaxations to acetylcholine involve either NO or the combination of NO plus a product of cyclo‐oxygenase but not EDHF; in the eNOS(−/−) mice, NO‐dependent responses and EDHF‐like responses were not observed.
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Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats.
O Della-Zuana,Françoise Presse,Christine Ortola,Jacques Duhault,Jean-Louis Nahon,Nigel Levens +5 more
TL;DR: The results strongly suggest that MCH is an orexigenic peptide involved in the control of both short- and long term food intake in satiated rats and further indicate that the MCH pathway is a possible target for theControl of food intake and obesity.
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Cannabinoid CB1 receptor and endothelium‐dependent hyperpolarization in guinea‐pig carotid, rat mesenteric and porcine coronary arteries
Thierry Chataigneau,Michel Félétou,Catherine Thollon,Nicole Villeneuve,Jean-Paul Vilaine,Jacques Duhault,Paul M. Vanhoutte +6 more
TL;DR: Whether or not the endothelium‐dependent hyperpolarizations of the vascular smooth muscle cells (observed in the presence of inhibitors of nitric oxide synthase and cyclo‐oxygenase) can be attributed to the production of an endogenous cannabinoid is investigated.
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Food intake regulation in rodents : Y5 or Y1 NPY receptors or both?
Jacques Duhault,Michele Boulanger,Susana Chamorro,Jean A. Boutin,Odile Della Zuana,Emmanuelle Douillet,Jean-Luc Fauchère,Michel Félétou,Martine Germain,Bruno Husson,Vega Antonio Monge,Pierre Renard,Françoise Tisserand +12 more
TL;DR: Results do not allow one to conclude on the implication of a single receptor subtype at the molecular level, but this approach is crucial for the design of novel NPY receptor antagonists with potential use as anti-obesity drugs and for evaluation of their possible adverse peripheral side effects, such as hypotension.
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Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade.
O Della Zuana,M Sadlo,Martine Germain,Michel Félétou,Susana Chamorro,Françoise Tisserand,C de Montrion,J F Boivin,Jacques Duhault,Jean A. Boutin,Nigel Levens +10 more
TL;DR: It is concluded that CGP 71683A is an imprecise tool for investigating the role of the NPY Y5 receptor in the control of physiological processes including food intake and an inflammatory response associated with the fall in food intake is demonstrated.
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