Jacquelyn Sousa
University of Massachusetts Medical School
15 Papers
6 Citations
Jacquelyn Sousa is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Small interfering RNA & Gene silencing. The author has an hindex of 3, co-authored 4 publications.
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Papers
Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1
Sarah M. Davis,Vignesh Narayan Hariharan,Agnes Lo,Anton A. Turanov,Dimas Echeverria,Jacquelyn Sousa,Nicholas McHugh,Annabelle Biscans,Julia F. Alterman,S. Ananth Karumanchi,Melissa J. Moore,Anastasia Khvorova +11 more
TL;DR: In this article , small interfering RNAs (siRNAs) targeting sFLT1 mRNA were injected into pregnant mice or baboons to reduce placental over-expression of placental soluble fms-like tyrosine kinase 1 and ameliorate clinical signs of preeclampsia.
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Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
Vignesh Narayan Hariharan,Minwook Shin,Ching-Wen Chang,Daniel O'Reilly,Annabelle Biscans,Ken Yamada,Zhiru Guo,Mohan Somasundaran,Qi Tang,Kathryn R. Monopoli,Pranathi Meda Krishnamurthy,G.Dharani Devi,Nicholas McHugh,David A. Cooper,Dimas Echeverria,John Cruz,Io Long Chan,Ping Liu,Sun-Young Lim,Jill McConnell,Satya Prakash Singh,Samuel R. Hildebrand,Jacquelyn Sousa,Sarah M. Davis,Zachary Kennedy,Chantal M. Ferguson,Bruno M.D.C. Godinho,Yann Thillier,Jillian Caiazzi,Socheata Ly,Manish Muhuri,Karen A. Kelly,Fiachra Humphries,Alyssa Cousineau,Krishna Mohan Parsi,Qi Li,Yan Wang,René Maehr,Guangping Gao,Dmitry Korkin,William M. McDougall,Robert W. Finberg,Katherine A. Fitzgerald,Jennifer P. Wang,Jonathan K. Watts,Anastasia Khvorova +45 more
TL;DR: In this paper , the authors performed a comprehensive screening of siRNA chemical architectures and identified an effective multimeric platform for local lung delivery, using this platform, they designed and screened over 200 siRNAs and antisense oligonucleotides targeting highly conserved regions within the SARS-CoV-2 genome.
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Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Qi Tang,Hassan H. Fakih,Mohammad Zain Ui Abideen,Samuel R. Hildebrand,Khashayar Afshari,Katherine Y Gross,Jacquelyn Sousa,Allison S Maebius,Christina Bartholdy,Pia Pernille Søgaard,Malene Jackerott,Vignesh Narayan Hariharan,Ashley Summers,Xueli Fan,K. Okamura,Kathryn R. Monopoli,David A Cooper,Dimas Echeverria,Brianna Bramato,Nicholas McHugh,Raymond C Furgal,Karen Dresser,Sarah J Winter,Annabelle Biscans,Jane Chuprin,Nazgol-Sadat Haddadi,Shany Sherman,Ümmügülsüm Yıldız-Altay,Mehdi Rashighi,Jillian M. Richmond,Claire Bouix-Peter,Carine Blanchard,Adam J. Clauss,Julia F. Alterman,Anastasia Khvorova,John E. Harris +35 more
TL;DR: This work rationally design small interfering RNAs (siRNAs) that offer sequence-specific gene silencing of JAK1, narrowing the spectrum of action on JAK-dependent cytokine signaling to maintain efficacy and improve safety and establishes a path toward siRNA treatments as a new class of therapeutic modality for inflammatory and autoimmune skin diseases.
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Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts
Minwook Shin,Io Long Chan,Yuming Cao,Alisha M. Gruntman,Jonathan M. Lee,Jacquelyn Sousa,Tomás Rodríguez,Dimas Echeverria,G.Dharani Devi,Alexandre J. Debacker,Michael P. Moazami,Pranathi Meda Krishnamurthy,Julia M Rembetsy-Brown,Karen A. Kelly,Onur Yukselen,Elisa Donnard,Teagan Parsons,Anastasia Khvorova,Erik J. Sontheimer,René Maehr,Manuel Garber,Jonathan K. Watts +21 more
TL;DR: In this article , the authors demonstrate that intratracheally administered LNA gapmer ASOs robustly induce gene silencing in lung fibroblasts, with significant silencing also in endothelial cells.
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Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease.
Chantal M. Ferguson,Samuel R. Hildebrand,Bruno Godinho,Julianna E. Buchwald,Dimas Echeverria,Andrew Coles,Anastasia Grigorenko,Lorenc Vangjeli,Jacquelyn Sousa,Nicholas McHugh,Matthew R. Hassler,Francesco Santarelli,Michael T Heneka,Evgeny Rogaev,Anastasia Khvorova +14 more
TL;DR: SiRNA-based modulation of Apoe is established as a viable therapeutic approach, immune activation as a key pathway affected by Apoe modulation is highlighted, and the technology to further evaluate the impact of APOE silencing on neurodegeneration is provided.
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