Jacqueline Lessig
Leipzig University
10 Papers
106 Citations
Jacqueline Lessig is an academic researcher from Leipzig University. The author has contributed to research in topics: Myeloperoxidase & Drug delivery. The author has an hindex of 9, co-authored 10 publications. Previous affiliations of Jacqueline Lessig include Nanyang Technological University.
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Papers
Layer-by-layer nanoparticles as an efficient siRNA delivery vehicle for SPARC silencing.
Yang Fei Tan,Raghavendra C. Mundargi,Min Hui Averil Chen,Jacqueline Lessig,Björn Neu,Subbu S. Venkatraman,Tina T. Wong +6 more
TL;DR: The LbL NP system described provides a promising, safe and efficient delivery platform as a non-viral vector for siRNA delivery that uses biopolymers to enhance the gene knock down efficiency for the development of siRNA therapeutics.
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Non-vital polymorphonuclear leukocytes express myeloperoxidase on their surface.
TL;DR: While only a very small percentage of freshly isolated cells was able to bind the MPO antibody, PMN suspensions cultured for 36 h or longer time periods contained an increasing number of cells able to interact with these antibodies, which may indicate a role of myeloperoxidase in apoptosis of PMNs.
Human Thy-1 induces secretion of matrix metalloproteinase-9 and CXCL8 from human neutrophils.
TL;DR: The results support the general concept that the function of ‘adhesion molecules’ in particular of human Thy‐1, may not only be to provide mechanical support but also regulate neutrophil functions.
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Differential effects of flavonols on inactivation of α1-antitrypsin induced by hypohalous acids and the myeloperoxidase–hydrogen peroxide–halide system
TL;DR: With this complex formation, myeloperoxidase overcomes the natural antioxidative protective system of plasma and prevents the inactivation of alpha1-antitrypsin.
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Destabilization of the acrosome results in release of phospholipase A2 from human spermatozoa and subsequent formation of lysophospholipids.
Jacqueline Lessig,Hans-Jürgen Glander,Jürgen Schiller,Marijana Petković,Uwe Paasch,Juergen Arnhold +5 more
TL;DR: The results demonstrated that destabilization of the acrosome is able to induce a release of secretory phospholipase A2 from human spermatozoa with subsequent generation of lysophosphocholine in the surrounding of spermatozosa.
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