Jacob Taylor
Broad Institute
22 Papers
89 Citations
Jacob Taylor is an academic researcher from Broad Institute. The author has contributed to research in topics: Biology & Mental health. The author has an hindex of 13, co-authored 20 publications. Previous affiliations of Jacob Taylor include George Washington University & Brigham and Women's Hospital.
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Papers
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Daniel J. Weiner,Daniel J. Weiner,Emilie M. Wigdor,Emilie M. Wigdor,Stephan Ripke,Raymond K. Walters,Raymond K. Walters,Jack A. Kosmicki,Jakob Grove,Kaitlin E. Samocha,Kaitlin E. Samocha,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Aysu Okbay,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Thomas Werge,Thomas Werge,Thomas Werge,David M. Hougaard,Jacob Taylor,David Skuse,Bernie Devlin,Richard Anney,Stephen Sanders,Somer L. Bishop,Preben Bo Mortensen,Preben Bo Mortensen,Anders D. Børglum,Anders D. Børglum,George Davey Smith,Mark J. Daly,Mark J. Daly,Elise B. Robinson,Elise B. Robinson +34 more
TL;DR: It is found that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant, and elements of polygenic risk are independent and differ in their relationship with phenotype.
Advocacy for mental health: roles for consumer and family organizations and governments
TL;DR: Mental health advocacy is one of the pillars to improve mental health care and the human rights of people with mental disorders and it is hoped the recommendations in this article will help government officials and activists to strengthen national advocacy movements.
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Meta-analysis of genetic association studies on bipolar disorder.
Fayaz Seifuddin,Pamela B. Mahon,Jennifer Toolan Judy,Mehdi Pirooznia,Dubravka Jancic,Jacob Taylor,Fernando S. Goes,James B. Potash,Peter P. Zandi +8 more
TL;DR: A meta‐analysis of published candidate gene studies of BP found that none of the findings were significant after correction for multiple testing, highlighting the need for more atheoretical approaches to study the genetics of BP afforded by GWAS.
Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency
Phillip L. Pearl,K. M. Gibson,Zenaide M.N. Quezado,Irene H. Dustin,Jacob Taylor,Stacey Trzcinski,John M. Schreiber,K. Forester,Patricia Reeves-Tyer,Clarissa J. Liew,Sadat Shamim,Peter Herscovitch,Richard E. Carson,John A. Butman,C.A.J.M. Jakobs,William H. Theodore +15 more
TL;DR: The results suggest that high endogenous brain GABA levels in SSADH deficiency downregulate GABA(A)-BZPR binding site availability, and suggests that PET may be useful to translate studies in animal models to human disease.
Inherited disorders of GABA metabolism.
TL;DR: The inherited disorders of γ-amino butyric acid metabolism require an increased index of clinical suspicion as discussed by the authors, which requires cerebrospinal fluid for detection, thus allowing for the possibility that these entities, as in the other inherited neurotransmitter disorders, are under-recognized.
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