Jacob Kahn
8 Papers
715 Citations
Jacob Kahn is an academic researcher. The author has contributed to research in topics: Neurofilament & Alzheimer's disease. The author has an hindex of 6, co-authored 8 publications.
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Papers
Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants
Brian H. Anderton,Deryck Breinburg,Malcolm J. Downes,Philip J. Green,B. E. Tomlinson,Jürg Ulrich,John N. Wood,John N. Wood,Jacob Kahn +8 more
TL;DR: Monoclonal antibodies are used to show here that neurofilament antigens are present in neurofibrillary tangles, a prominent feature in the pyramidal cells of the hippocampus and in neurones of the cerebral cortex of people suffering from senile dementia of the Alzheimer type.
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Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants
Brian H. Anderton,Deryck Breinburg,Malcolm J. Downes,Philip J. Green,B. E. Tomlinson,Jürg Ulrich,John N. Wood,Jacob Kahn +7 more
TL;DR: In this paper, the authors used monoclonal antibodies to show that neurofilament antigens are present in neurofibrillary tangles, which may be either neurofilaments3 or microtubules5.
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Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.
TL;DR: Three monoclonal antibodies to neurofilaments (RT97, BF10 and 147), two of which also recognised neurofibrillary tangles, have all been shown to be specific for phosphorylated epitopes.
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Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies.
C. G. Rasool,Carmela R. Abraham,Brian H. Anderton,Margaret Haugh,Jacob Kahn,Dennis J. Selkoe +5 more
TL;DR: It is concluded that neurofibrillary tangles in Alzheimer's disease are heterogeneous as regards their filamentous content and contain both antigen cross-reacting with neurofilaments and antigens which are apparently unique to PHF and not shared with normal neurofilament proteins.
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The cytoskeleton and neurofibrillary tangles in Alzheimer's disease
TL;DR: The study of the structure and composition of neurofibrillary tangles is an important area of research, since it may reveal how they are produced and so help to elucidate the degenerative processes which underlie this devastating disease.
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