Jacob Haase
Martin Luther University of Halle-Wittenberg
10 Papers
2 Citations
Jacob Haase is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: microRNA & Biology. The author has an hindex of 5, co-authored 10 publications.
Chat about Author
Papers
The Critical Role of RNA m6A Methylation in Cancer
TL;DR: Screening for selective and potent RNA methyltransferase, demethylase, or m6A-binding protein inhibitors may lead to compounds suitable for future clinical trials in cancer patients.
698
IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner
Simon Müller,Markus Glaß,Anurag Kumar Singh,Jacob Haase,Nadine Bley,Tommy Fuchs,Marcell Lederer,Andreas Dahl,Huilin Huang,Huilin Huang,Jianjun Chen,Jianjun Chen,Guido Posern,Stefan Hüttelmaier +13 more
TL;DR: Findings identify the SRF/IGF2BP1, miRNome- and m6A-dependent control of gene expression as a conserved oncogenic driver network in cancer.
341
The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer.
Simon Müller,Nadine Bley,Bianca Busch,Markus Glaß,Marcell Lederer,Claudia Misiak,Tommy Fuchs,Alice Wedler,Jacob Haase,Jean B. Bertoldo,Patrick Michl,Stefan Hüttelmaier +11 more
TL;DR: It is revealed that IGF2BP1 is a post-transcriptional enhancer of the E2F-driven hallmark in solid cancers, and the small molecule BTYNB disrupts this enhancer function by impairing IGF2 BP1-RNA association.
Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning
Nadine Körtel,Cornelia Rücklé,You Zhou,Anke Busch,Peter Hoch-Kraft,F. X. Reymond Sutandy,Jacob Haase,Mihika Pradhan,Michael U. Musheev,Dirk H. Ostareck,Antje Ostareck-Lederer,Christoph Dieterich,Stefan Hüttelmaier,Christof Niehrs,Oliver Rausch,Dan Dominissini,Julian König,Kathi Zarnack +17 more
TL;DR: Wang et al. as discussed by the authors presented miCLIP2 in combination with machine learning to significantly improve m6A detection and established a robust computational pipeline to tackle the inherent issue of false positives.
78
Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.
Hung Ho-Xuan,Petar Glažar,Claudia Latini,Kevin Heizler,Jacob Haase,Robert Hett,Marvin Anders,Franziska Weichmann,Astrid Bruckmann,Debbie L. C. van den Berg,Stefan Hüttelmaier,Nikolaus Rajewsky,Christina Hackl,Gunter Meister +13 more
TL;DR: It is reported that the ORF of circZNF609 is efficiently translated when expressed from a circZ NF609 overexpression construct, however, endogenous proteins could not be detected and underline that circRNA overexposure constructs need to be evaluated carefully, particularly when functional studies are performed.