Jacob E. Moskowitz
University of Missouri
12 Papers
16 Citations
Jacob E. Moskowitz is an academic researcher from University of Missouri. The author has contributed to research in topics: Biology & Gut flora. The author has an hindex of 4, co-authored 9 publications. Previous affiliations of Jacob E. Moskowitz include Cedars-Sinai Medical Center & Case Western Reserve University.
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Papers
Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans
Connie W.Y. Ha,Anthony Martin,Gregory D. Sepich-Poore,Baochen Shi,Yizhou Wang,Kenneth Gouin,Gregory Humphrey,Karenina Sanders,Yasiru Ratnayake,Kelvin S.L. Chan,Gustaf Hendrick,J.R. Caldera,Christian Arias,Jacob E. Moskowitz,Shannan J. Ho Sui,Shaohong Yang,David M. Underhill,Matthew J. Brady,Simon R.V. Knott,Kelly Kaihara,Michael J. Steinbaugh,Huiying Li,Dermot P.B. McGovern,Rob Knight,Phillip Fleshner,Suzanne Devkota +25 more
TL;DR: A subset of mucosal-associated gut bacteria that consistently translocated and remained viable in CrF in CD ileal surgical resections is discovered, and Clostridium innocuum is identified as a signature of this consortium with strain variation between mucosal and adipose isolates, suggesting preference for lipid-rich environments.
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Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance
TL;DR: Heterozygous mutations in two core subunits of Polycomb Repressive Complex 2 (PRC2), the histone H3 lysine 27 (H3K27)-specific methyltransferase E(Z) and its partner, the H3 binding protein ESC, increase longevity and reduce adult levels of trimethylated H3K26me3 are reported.
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Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation.
Jacob E. Moskowitz,Jacob E. Moskowitz,Anthony G. Doran,Anthony G. Doran,Zhentian Lei,Susheel Bhanu Busi,Marcia L. Hart,Craig L. Franklin,Lloyd W. Sumner,Thomas M. Keane,Thomas M. Keane,James M. Amos-Landgraf +11 more
TL;DR: It is found that both genetic variation and differences in microbiota influences the quantitiative adenoma phenotype in Apc Min mice, and the power of a multi-omics approach to dissect complex disease susceptibility of noncoding variants is illustrated.
The gut microbiota modulates differential adenoma suppression by B6/J and B6/N genetic backgrounds in Apc Min mice
TL;DR: It is shown that B 6/J and B6/N have modifier effects on Min, and these effects are further altered by the complex GM, and strict attention to genetic background and environmental variables influencing the GM is critical to enhance reproducibility in models of complex disease traits.
Interactions of Segmented Filamentous Bacteria (Candidatus Savagella) and bacterial drivers in colitis-associated colorectal cancer development
TL;DR: Testing the ability of the Th17-enhancing commensal Candidatus Savagella to influence the incidence and severity of colitis-associated CRC in male and female mice supported sex-dependent SFB-mediated effects on CRC risk, and highlighted the complex community dynamics within the GM during exposure to inflammatory pathobionts.