Jacob A. Johnson
Auburn University
8 Papers
5 Citations
Jacob A. Johnson is an academic researcher from Auburn University. The author has contributed to research in topics: Transduction (genetics) & Gene delivery. The author has an hindex of 6, co-authored 8 publications.
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Papers
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
Sourav Roy Choudhury,Zachary Fitzpatrick,Anne F Harris,Stacy Maitland,Jennifer S Ferreira,Yuanfan Zhang,Shan Ma,Rohit Sharma,Heather L. Gray-Edwards,Jacob A. Johnson,Aime K. Johnson,Laura C. Alonso,Claudio Punzo,Kathryn R. Wagner,Casey A. Maguire,Robert M. Kotin,Douglas R. Martin,Miguel Sena-Esteves +17 more
TL;DR: The isolation of a novel CNS tropic AAV capsid, AAV-B1, after a single round of in vivo selection from an AAV Capsid library is reported, which represents an important improvement over AAV9 for CNS gene therapy.
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Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector
Sourav Roy Choudhury,Anne F Harris,Damien J. Cabral,Allison M. Keeler,Ellen Sapp,Jennifer S Ferreira,Heather L. Gray-Edwards,Jacob A. Johnson,Aime K. Johnson,Qin Su,Lorelei Stoica,Marian DiFiglia,Neil Aronin,Douglas R. Martin,Guangping Gao,Miguel Sena-Esteves +15 more
TL;DR: This work investigated the possibility of improving CNS transduction of existing AAV capsids by genetically fusing peptides to the N-terminus of VP2 capsid protein, and found a novel vector AAV-AS, generated by the insertion of a poly-alanine peptide, is capable of extensive gene transfer throughout the CNS after systemic administration in adult mice.
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Adeno-Associated Virus Gene Therapy in a Sheep Model of Tay–Sachs Disease
Heather L. Gray-Edwards,Ashley N. Randle,Stacy Maitland,Hector R Benatti,Spencer M Hubbard,Peter F Canning,Matthew B Vogel,Brandon L. Brunson,Misako Hwang,Lauren E. Ellis,Allison M. Bradbury,Atoska S. Gentry,Amanda R. Taylor,Anne A. Wooldridge,Dewey R. Wilhite,Randolph L. Winter,Brian K Whitlock,Jacob A. Johnson,Merilee Holland,Nouha Salibi,Ronald J. Beyers,James L. Sartin,Thomas S. Denney,Nancy R. Cox,Miguel Sena-Esteves,Douglas R. Martin +25 more
TL;DR: This report demonstrates therapeutic efficacy for TSD in the sheep brain, which is on the same order of magnitude as a child's brain.
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Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease
Victoria J. McCurdy,Hannah E. Rockwell,Julian R. Arthur,Allison M. Bradbury,Aime K. Johnson,Ashley N. Randle,Brandon L. Brunson,Misako Hwang,Heather L. Gray-Edwards,Nancy E. Morrison,Jacob A. Johnson,Henry J. Baker,Nancy R. Cox,Thomas N. Seyfried,Miguel Sena-Esteves,Douglas R. Martin +15 more
TL;DR: In this article, Adeno-associated virus (AAV) gene therapy achieved global CNS Hex restoration and widespread normalization of storage in the Sandhoff disease (SD) mouse model using a similar treatment approach, and they sought to translate the outcome in mice to the feline SD model as an important step toward human clinical trials.
72
Effect of PO Administered Gabapentin on Chronic Lameness in Horses
Fred J. Caldwell,Jennifer Taintor,R. Wayne Waguespack,Glen Sellers,Jacob A. Johnson,H. C. Lin +5 more
TL;DR: The clinical effectiveness of gabapentin as an analgesic in horses with chronic lameness was evaluated in a double-blinded crossover study.
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