Jacky Jacquot
University of Reims Champagne-Ardenne
87 Papers
1.1K Citations
Jacky Jacquot is an academic researcher from University of Reims Champagne-Ardenne. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 29, co-authored 85 publications. Previous affiliations of Jacky Jacquot include French Institute of Health and Medical Research & Pierre-and-Marie-Curie University.
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Papers
Inflammation and Infection in Naive Human Cystic Fibrosis Airway Grafts
Rabindra Tirouvanziam,S de Bentzmann,C. Hubeau,Jocelyne Hinnrasky,Jacky Jacquot,Bruno Péault,E. Puchelle +6 more
TL;DR: It is demonstrated that before any infection, CF airways are in a proinflammatory state, and after infection, the basal inflammatory imbalance contributes to exert severe damage to the mucosa, paving the way for bacterial colonization and subsequent steps of CF airway disease.
253
Selective Up-Regulation of Chemokine IL-8 Expression in Cystic Fibrosis Bronchial Gland Cells in Vivo and in Vitro
Olivier Tabary,J.M. Zahm,Jocelyne Hinnrasky,Jean Paul Couetil,Pascale Cornillet,Moncef Guenounou,Dominique Gaillard,Edith Puchelle,Jacky Jacquot +8 more
TL;DR: The selective up-regulation of bronchial submucosal gland IL-8 could represent a primary event that initiates early airway sub mucosal inflammation in CF patients, and is relevant to the pathogenesis of CF.
178
Airway epithelial cell inflammatory signalling in cystic fibrosis
Jacky Jacquot,Olivier Tabary,Olivier Tabary,Philippe Le Rouzic,Philippe Le Rouzic,Annick Clement,Annick Clement +6 more
TL;DR: The current understanding of the molecular mechanisms by which airway epithelial cells contribute to abnormal lung inflammation in CF, as well as the anti-inflammatory strategies that can be proposed are discussed.
133
•Journal Article
Localization of the cystic fibrosis transmembrane conductance regulator in airway secretory glands
Jacky Jacquot,E. Puchelle,Hinnrasky J,C Fuchey,C Bettinger,C. Spilmont,N Bonnet,A Dieterle,D Dreyer,A Pavirani +9 more
TL;DR: The data suggest that in airway tissues, CFTR could be involved in intracellular processes of the mucus exocytosis in submucosal secretory glands.
123
Involvement of toll-like receptor 4 in the inflammatory reaction induced by hydroxyapatite particles
Alexia Grandjean-Laquerriere,Olivier Tabary,Jacky Jacquot,Doriane Richard,Patrick Frayssinet,Moncef Guenounou,Dominique Laurent-Maquin,Patrice Laquerriere,Sophie C. Gangloff +8 more
TL;DR: It is shown for the first time that the production of TNF-alpha by macrophages exposed to HA particles was TLR4 dependent but not the activation of NF-kappaB, which open future therapies to reduce the inflammatory response induced by HA biomaterials.
121