Jackson B. Trotman
University of North Carolina at Chapel Hill
11 Papers
16 Citations
Jackson B. Trotman is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: RNA & XIST. The author has an hindex of 4, co-authored 11 publications. Previous affiliations of Jackson B. Trotman include Ohio State University.
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Papers
The control of polycomb repressive complexes by long noncoding RNAs.
Jackson B. Trotman,Keean C.A. Braceros,Rachel E Cherney,McKenzie M. Murvin,J. Mauro Calabrese +4 more
TL;DR: The polycomb repressive complexes 1 and 2 (PRCs; PRC1 and PRC2) are conserved histone-modifying enzymes that often function cooperatively to repress gene expression as discussed by the authors.
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RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome
Jackson B. Trotman,Bernice A. Agana,Andrew J. Giltmier,Vicki H. Wysocki,Daniel R. Schoenberg +4 more
TL;DR: Nuclear and cytoplasmic CEs were exquisitely sensitive to inhibition of HSP90, with both forms declining significantly following treatment with each of several HSP 90 inhibitors, raising the possibility that the cytotoxic effect of these drugs may partially be due to a general reduction in translatable mRNAs.
9
Elements at the 5′ end of Xist harbor SPEN-independent transcriptional antiterminator activity
Jackson B. Trotman,David M Lee,Rachel E Cherney,Susan O Kim,Susan O Kim,Kaoru Inoue,Kaoru Inoue,Megan D. Schertzer,Steven R. Bischoff,Dale O. Cowley,J. Mauro Calabrese +10 more
TL;DR: Xist requires sequence elements beyond its first two kilobases to robustly silence transcription, and the 5′ end of Xist harbors SPEN-independent transcriptional antiterminator activity that can repress proximal cleavage and polyadenylation.
8
How to silence an X chromosome
TL;DR: The non-coding RNA Xist has been shown to enlist the SPEN protein to recruit a team of protein complexes — initiating the process that prevents transcription of one of the two X chromosomes found in female mammalian cells.
6
A 5′ fragment of Xist can sequester RNA produced from adjacent genes on chromatin
David M Lee,Jackson B. Trotman,Rachel E Cherney,Kaoru Inoue,Megan D. Schertzer,Steven R. Bischoff,Dale O. Cowley,J. Mauro Calabrese +7 more
TL;DR: It is proposed that sequestration is mechanistically related to the Repeat-A dependent stabilization and tethering of Xist near actively transcribed regions of chromatin.