Jacklyn Goddard
6 Papers
Jacklyn Goddard is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 4 publications.
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Papers
Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development
Daniel Williamson,Edward C. Schwalbe,Debbie Hicks,Kimberly A. Aldinger,Janet C. Lindsey,Stephen Crosier,Stacey Richardson,Jacklyn Goddard,Rebecca M Hill,Jemma Castle,Yura Grabovska,J Hacking,Barry Pizer,Stephen B. Wharton,Thomas S. Jacques,Abhijit Joshi,Simon Bailey,Steven C. Clifford +17 more
TL;DR: Using RNA sequencing (RNA-seq) in large, well-annotated cohorts of medulloblastoma, this paper showed that transcriptionally group 3 and group 4 entities exist as intermediates on a bipolar continuum.
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Predicting outcomes of hematological malignancy patients admitted to critical care
Ascanio Tridente,Nina C. Dempsey,Mai S. Khalifa,Jacklyn Goddard,Katy Shuker,J. Hall,Y. Sorour,Josh Wright,S. Webber,Gary H. Mills,John A. Snowden +10 more
- 17 Mar 2023
TL;DR: In this paper , a large cohort of adult malignancy patients (n=437) admitted to CC over a sixteen-year period, with the specific aim of identifying risk factors present at CC unit admission that could help to predict outcome.
MEDB-71. Molecular characterisation of group 4 medulloblastoma improves risk-stratification and its biological understanding
Jacklyn Goddard,J. David Castle,Emily Southworth,Anya Fletcher,Stephen Crosier,Idoia Martin-Guerrero,Miguel Garcia-Ariza,Aurora Navajas,Julien Masliah-Planchon,Franck Bourdeaut,Christelle Dufour,Tobias Goschizk,Torsten Pietsch,Stacey Richardson,Rebecca M Hill,Daniel Williamson,Simon Bailey,Edward C. Schwalbe,Steven C. Clifford,Debbie Hicks +19 more
TL;DR: Comprehensive clinico-molecular assessment of MBGrp4 provides important understanding of its clinical and biological heterogeneity and removes standard risk disease and identifies a favourable risk group (20% of MB Grp4) with potential for therapy de-escalation.
The clinical significance of sub-total surgical resection in childhood medulloblastoma: a multi-cohort analysis of 1100 patients
Claire Keeling,Simon Davies,Jacklyn Goddard,Vijay Ramaswamy,Edward C. Schwalbe,Simon Bailey,Debbie Hicks,Steven C. Clifford +7 more
TL;DR: The data suggest that maximal safe resection can continue to be carried out for patients with medulloblastoma and suggest STR should not inform patient management when observed as a sole, isolated risk-feature.
P1102: ibrutinib and rituximab as first line therapy for mantle cell lymphoma: updated outcomes from a multicentre, real-world uk study
Rohan Shotton,A. M. Tivey,Toby A. Eyre,David J. Lewis,Rebecca L. Allchin,Harriet S. Walter,Fiona Miall,Rui Zhao,A. Santarsieri,Rory McCulloch,Mark Bishton,Victoria Willimott,Nicole R. Fowler,Claudia Bedford,Jacklyn Goddard,Samuel Protheroe,Mahesh Prahladan,Miriam Reeve,Shankara Paneesha,Helen Marr,Jamie Wilson,Kushani Ediriwickrema,Chloe Knott,D Wrench,Georgina Talbot,Kim Linton +25 more
TL;DR: In this real-world study of mostly transplant ineligible MCL pts, first line IBR +/R was well tolerated and effective, especially in pts with low risk disease, which suggests that novel approaches should be considered in those with aggressive MCL biology.