Jack Reilly
University of Western Ontario
12 Papers
Jack Reilly is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Biology & DNA methylation. The author has an hindex of 2, co-authored 4 publications. Previous affiliations of Jack Reilly include London Health Sciences Centre.
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Papers
Clinical Validation of Copy Number Variant Detection from Targeted Next-Generation Sequencing Panels
Jennifer Kerkhof,Laila C. Schenkel,Jack Reilly,Sheri McRobbie,Erfan Aref-Eshghi,Alan Graham Stuart,C. Anthony Rupar,C. Anthony Rupar,Paul C. Adams,Robert A. Hegele,Hanxin Lin,Hanxin Lin,David I. Rodenhiser,Joan H.M. Knoll,Joan H.M. Knoll,Peter Ainsworth,Peter Ainsworth,Bekim Sadikovic,Bekim Sadikovic +18 more
TL;DR: This NGS CNV pipeline enables stand-alone first-tier assessment for CNV and sequence variants in a clinical laboratory setting, dispensing with the need for parallel CNV analysis using classic techniques, such as microarray, long-range PCR, or multiplex ligation-dependent probe amplification.
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Clinical Next-Generation Sequencing Pipeline Outperforms a Combined Approach Using Sanger Sequencing and Multiplex Ligation-Dependent Probe Amplification in Targeted Gene Panel Analysis.
Laila C. Schenkel,Jennifer Kerkhof,Alan Graham Stuart,Jack Reilly,Barry Eng,Crystal Woodside,Alexander Levstik,Christopher J. Howlett,Anthony Rupar,Anthony Rupar,Joan H.M. Knoll,Joan H.M. Knoll,Peter Ainsworth,Peter Ainsworth,John S. Waye,Bekim Sadikovic,Bekim Sadikovic +16 more
TL;DR: A standardized NGS pipeline designed to replace Sanger sequencing and multiplex ligation-dependent probe amplification analysis and to facilitate detection of sequence and copy number alterations in a single test focusing on a BRCA1/BRCA2 gene analysis panel is clinically validated.
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Functional correlation of genome‐wide DNA methylation profiles in genetic neurodevelopmental disorders
Michael D. Levy,R. T. Relator,H. McConkey,Erinija Pranckeviciene,Jennifer Kerkhof,Mouna Barat-Houari,Sara Bargiacchi,Elisa Biamino,M Palomares Bralo,Gerarda Cappuccio,Andrea Ciolfi,Angus John Clarke,Barbara R. DuPont,Mariet W. Elting,Laurence Faivre,Timothy Fee,Marco Ferilli,Robin S. Fletcher,Florian Cherick,Aidin Foroutan,Michael J. Friez,Cristina Gervasini,Sadegheh Haghshenas,Benjamin Hilton,Zandra A. Jenkins,Simranpreet Kaur,Suzanne K Lewis,Raymond J. Louie,Silvia Maitz,Donatella Milani,Angela T Morgan,Renske Oegema,Elsebet Østergaard,Nathalie Pallarès,Maria Piccione,Astrid S. Plomp,Cathryn Poulton,Jack Reilly,Rocio Rius,Stephen P. Robertson,Kathleen Rooney,Justine Rousseau,Gijs W. E. Santen,Fernando Santos-Simarro,J.M.C. Schijns,Gabriella Maria Squeo,Miya John,Christel Thauvin-Robinet,Giovanna Traficante,Pleuntje J. van der Sluijs,Samantha A. Schrier Vergano,Niels Vos,Kellie K. Walden,Dimitar N. Azmanov,Tugce B. Balci,Siddharth Banka,Jozef Gecz,Peter Henneman,Jennifer A. Lee,Marcel M.A.M. Mannens,Tony Roscioli,Victoria Mok Siu,David J. Amor,Gareth Baynam,Eric G. Bend,Kym M. Boycott,Nicola Brunetti-Pierri,Philippe M. Campeau,Dominique Campion,John Christodoulou,David A. Dyment,Natacha Esber,Jill A. Fahrner,Mark D. Fleming,David Geneviève,Delphine Héron,Thomas Husson,Kristin D. Kernohan,Alisdair McNeill,Leonie A. Menke,Giuseppe Merla,Paolo Prontera,Cheryl Rockman-Greenberg,Charles E. Schwartz,Steven A. Skinner,Roger E. Stevenson,Marie Vincent,Antonio Vitobello,Marco Tartaglia,Marielle Alders,Matt Tedder,Bekim Sadikovic +91 more
TL;DR: Evidence of correlation between the function of the mutated genes and the consequent genomic DNA methylation profiles as a key functional element in the molecular etiology of genetic neurodevelopmental disorders is demonstrated.
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Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature
Richard H. van Jaarsveld,Jack Reilly,Marie Claire A. Cornips,Michael A. Hadders,Emanuele Agolini,Priyanka Ahimaz,Kwame Anyane-Yeboa,Severine Audebert Bellanger,Ellen van Binsbergen,M. J. van den Boogaard,Elise Brischoux-Boucher,Raymond Clinton Caylor,Andrea Ciolfi,Ton van Essen,Paolo Fontana,Saskia M. J. Hopman,Maria Iascone,Margaret M Javier,Erik-Jan Kamsteeg,Jennifer Kerkhof,Jun Kido,Hyung Goo Kim,Tjitske Kleefstra,Fortunato Lonardo,Abbe Lai,Dorit Lev,Michael D. Levy,M. E. Suzanne Lewis,Angie W. Lichty,Marcel M.A.M. Mannens,Naomichi Matsumoto,Idit Maya,H. McConkey,André Mégarbané,Vincent Michaud,Evelina Miele,Marcello Niceta,Antonio Novelli,Roberta Onesimo,Rolph Pfundt,Bernt Popp,Eloise J. Prijoles,R. T. Relator,Sylvia Redon,Dmitrijs Rots,Karen Rouault,Ken Saida,Jolanda H. Schieving,Marco Tartaglia,Romano Tenconi,Kévin Uguen,Nienke E. Verbeek,Christopher T. Walsh,Keren Yosovich,Christopher J. Yuskaitis,Giuseppe Zampino,Bekim Sadikovic,Marielle Alders,Renske Oegema +58 more
TL;DR: In this paper , a set of 27 individuals with heterozygous Lysine-demethylase 2B (KDM2B) variants are associated with NDD and a specific epigenetic signature detectable in peripheral blood.
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DNA methylation episignature in Gabriele-de Vries syndrome
Florian Cherik,Jack Reilly,Jennifer Kerkhof,Michael D. Levy,H. McConkey,Mouna Barat-Houari,Kameryn M. Butler,Christine Coubes,Jennifer A. Lee,Gwenaël Le Guyader,Raymond J. Louie,Wesley G. Patterson,Matt Tedder,Mads Bak,Trine Bjørg Hammer,William J. Craigen,Florence Demurger,Christèle Dubourg,Mélanie Fradin,Rachel Franciskovich,Eirik Frengen,Jennifer F. Friedman,Nathalie Ruiz Palares,Maria Iascone,Doriana Misceo,Pauline Monin,Sylvie Odent,Christophe Philippe,Flavien Rouxel,Veronica Saletti,Petter Strømme,Perla Thulin,Bekim Sadikovic,David Geneviève +33 more
TL;DR: In this article , the authors performed genome-wide DNA methylation analysis of a series of individuals carrying a YY1 variant of Gabriele-de Vries syndrome (GADEVS) to refine the phenotype and better understand the molecular basis of the syndrome.
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