The silanol group and its role in liquid chromatography

Is hydrophilic interaction chromatography with silica columns a viable alternative to reversed-phase liquid chromatography for the analysis of ionisable compounds?

Part II. Chromatography using ultra-stable metal oxide-based stationary phases for HPLC.

A pragmatic test procedure for comparison and evaluation of reversed phases is described. The differences in retention between RP8 and RP18 can be compensated for by adjustment of the eluent composition. A 10% increase in the water content doubles the k′ values, as does the exchange of an RP8 with an RP18 column. It is possible to differentiate between the two columns with the pair ethylbenzoate and toluene. Under stand-ard conditions (methanol-water, 55–45, v/v; 49–51, w/w) with RP8 ethylbenzoate is always eluted together or after toluene, whereas with RP18 it is always eluted in front of toluene.

Comparison and characterization of reversed phases

The challenges of the analysis of basic compounds by high performance liquid chromatography: some possible approaches for improved separations.

Separation of organic amine compounds on silica gel with reversed-phase eluents

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Separation of organic amine compounds on silica gel with reversed-phase eluents