Jack J. Chen
Procter & Gamble
16 Papers
278 Citations
Jack J. Chen is an academic researcher from Procter & Gamble. The author has contributed to research in topics: Solid-phase synthesis & Bicyclic molecule. The author has an hindex of 11, co-authored 16 publications.
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Papers
Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3).
Michael P. Clark,Kelly M. George,Roger G. Bookland,Jack J. Chen,Steven K. Laughlin,Kumar D. Thakur,Wenlin Lee,Jan Richard Davis,Ed J. Cabrera,Todd A. Brugel,John C. VanRens,Matthew J. Laufersweiler,Jennifer A. Maier,Mark Sabat,Adam Golebiowski,Vijay Easwaran,Mark E. Webster,Biswanath De,George Zhang +18 more
TL;DR: A new class of bicyclic pyrrolopyrimidine-based Janus kinase 3 (JAK-3) inhibitors are described and many of these inhibitors showed low nanomolar activity against Jak-3.
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Solid supported high-throughput organic synthesis of peptide β-turn mimetics via tandem Petasis reaction/diketopiperazine formation
TL;DR: In this article, a high-throughput organic synthesis of bicyclic diketopiperazines 1, β-turn mimetics, is described, starting from Merrifield resin-bound piperazine-2-carboxylic acid, first two (R 4 and R 5 ) side chains are introduced via the Petasis reaction and subsequent amide bond formation.
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Solid-Supported Synthesis of a Peptide β-Turn Mimetic
Adam Golebiowski,Sean R. Klopfenstein,Xia Shao,Jack J. Chen,Anny-Odile Colson,and Arthur L. Grieb,Anne F. Russell +6 more
TL;DR: The solid-supported synthesis of a bicyclic diketopiperazine, a potential peptide β-turn mimetic, is described and the Ugi reaction between the resin ester of α-N-Boc-diaminopropionic acid, α-bromo acid, aldehyde, and isocyanide is the key step in the proposed protocol.
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Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.
Jack J. Chen,Kumar D. Thakur,Michael P. Clark,Steven K. Laughlin,Kelly M. George,Roger G. Bookland,Jan Richard Davis,Edward J. Cabrera,Vijay Easwaran,Biswanath De,Y. George Zhang +10 more
TL;DR: A new class of pyrimidine-based Janus tyrosine kinase 3 (JAK3) inhibitors are described and many of these inhibitors showed low nanomolar activity against JAK3.
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Solid-supported synthesis of putative peptide beta-turn mimetics via Ugi reaction for diketopiperazine formation.
Adam Golebiowski,Julita Jozwik,Sean R. Klopfenstein,Anny-Odile Colson,Arthur L Grieb,Anne F. Russell,Vinit Rastogi,Conrad Diven,David E. Portlock,Jack J. Chen +9 more
TL;DR: The scope and limitations of the solid-supported synthesis of a bicyclic diketopiperazine, an internal, putative peptide beta-turn mimetic, are presented and application of cyclitive cleavage as the final step led to desired products in high purity.
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