Jack A. Brown
GlaxoSmithKline
11 Papers
56 Citations
Jack A. Brown is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Catalysis & Phosphine. The author has an hindex of 5, co-authored 11 publications. Previous affiliations of Jack A. Brown include University of Strathclyde & Loughborough University.
Chat about Author
Papers
The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange
Jack A. Brown,Alison Ruth Cochrane,Stephanie Irvine,William J. Kerr,Bhaskar Mondal,John Parkinson,Laura C. Paterson,Marc Reid,Tell Tuttle,Shalini Andersson,Göran N. Nilsson +10 more
TL;DR: A series of robust iridium(I) complexes bearing a sterically encumbered N-heterocyclic carbene ligand, alongside a phosphine ligand was synthesized and investigated in hydrogen isotope exchange processes as discussed by the authors.
New odourless protocols for efficient Pauson-Khand annulations.
TL;DR: An inexpensive and commercially available odourless additive, dodecyl methyl sulfide, has been shown to be a highly effective promoter in the Pauson-Khand cyclisation of both intra- and intermolecular substrates, affording good to excellent yields of cyclopentenone products.
20
Stereoselective Ir(III)-catalyzed dimerization reaction of enynes: an entry to functionalized polyunsaturated and cyclic systems
Mehdi Ez-Zoubir,Florent Le Boucher d'Herouville,Jack A. Brown,Virginie Ratovelomanana-Vidal,Véronique Michelet +4 more
TL;DR: The Ir(III) complex efficiently promotes the selective dimerization of 1,6-, 1,7-enynes and functionalized alkynes and results in the formation of head-to-head isomers with (E)-stereoselectivity.
18
Iridium-catalyzed hydroiodination of functionalized alkynes
TL;DR: In this paper, the efficiency of an Ir(I)/HI system has been studied, and two main pathways seemed to be involved, one based on an initial oxidative addition of HI to the Ir (I) complex and the other based on a π-activation of the alkyne moiety.
16
Stereoselective Ir(III)-Catalyzed Dimerization Reaction of Enynes: An Entry to Functionalized Polyunsaturated and Cyclic Systems.
Mehdi Ez-Zoubir,Florent Le Boucher d'Herouville,Jack A. Brown,Virginie Ratovelomanana-Vidal,Véronique Michelet +4 more
TL;DR: The iridium-catalyzed head-to-head dimerization of alkynes (I) and (III) leads selectively to (E)-alkenes (II and (IV) in moderate to high yields.
14