J. Van Damme
Katholieke Universiteit Leuven
124 Papers
3.1K Citations
J. Van Damme is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Chemokine & Cytokine. The author has an hindex of 54, co-authored 124 publications. Previous affiliations of J. Van Damme include National Institutes of Health & Catholic University of Leuven.
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Papers
Leukocyte recruitment by monocyte chemotactic proteins (MCPs) secreted by human phagocytes
TL;DR: Specific and sensitive radioimmunoassays for MCP-1 and IL-8 were developed to study the regulation of their secretion by leukocytes and to isolate and identify natural chemokines from mononuclear phagocytes and tumor cells.
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Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression.
TL;DR: In conclusion, the observations indicate that the constitutive MHC class I expression is regulated by autocrine production of IFN-beta 1 and TNF-alpha acts as an enhancer of the autocrineProduction ofIFN- beta 1, and consequently as an enhancement of the MHCclass I expression and viral protection.
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Bacterial lipopolysaccharide potentiates gamma interferon-induced cytotoxicity for normal mouse and rat fibroblasts.
TL;DR: It is shown that bacterial lipopolysaccharide (LPS), which alone has no effect on the viability of mouse fibroblasts, stimulates cell suicide induced by IFN-gamma, and heat-killed gram-negative but also gram-positive bacteria were found to enhance IFN -gamma-induced cell death.
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Different preparations of natural and recombinant human interleukin-6 (ifn-β2, bsf-2) similarly stimulate acute phase protein synthesis and uptake of α-aminoisobutyric acid by cultured rat hepatocytes
Joanna Bereta,A Kurdowska,Aleksander Koj,T Hirano,Tadamitsu Kishimoto,Walter Fiers,J. Van Damme,J Gauldie +7 more
TL;DR: It is concluded that IL-6 is the principal hepatocyte stimulating factor responsible for typical features of the acute phase response of liver cells.
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Single-cell analysis of macrophage chemotactic protein-1-regulated cytosolic Ca2+ increase in human adherent monocytes
Cinzia Bizzarri,Riccardo Bertini,Paola Bossù,Silvano Sozzani,A Mantovani,J. Van Damme,A Tagliabue,Diana Boraschi +7 more
TL;DR: Inhibition of chemokine-induced increase of [Ca2+]i by cholera or pertussis toxin indicated that MCP-1 and M CP-2 activate monocytes through different intracellular pathways, suggesting interaction with distinct receptors.
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