J. Troke
Imperial College London
8 Papers
149 Citations
J. Troke is an academic researcher from Imperial College London. The author has contributed to research in topics: Glucuronide & Transacylation. The author has an hindex of 8, co-authored 8 publications.
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Papers
The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy.
Julian L. Griffin,J. Troke,Lee A. Walker,Richard F. Shore,John C. Lindon,Jeremy K. Nicholson +5 more
TL;DR: The testis contains large amounts of creatine, of which a substantial proportion was shown to be extracellular using bipolar gradients to measure apparent diffusion coefficients and the tissue also contained relatively high amounts of uridine.
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High‐resolution diffusion and relaxation‐edited magic angle spinning 1H NMR spectroscopy of intact liver tissue
TL;DR: In this paper, spectral-editing using T1 and T2 relaxation times and apparent diffusion coefficients (ADCs) at variable diffusion times was used in conjunction with HRMAS 1H NMR spectroscopy at 14.1 T in liver tissue.
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HPLC/1H NMR spectroscopic studies of the reactive alpha-1-O-acyl isomer formed during acyl migration of S-naproxen beta-1-O-acyl glucuronide.
TL;DR: The first direct observation of the alpha-1-O-acyl isomer of a drug ester glucuronide (S-naproxen) formed in a biosystem via the facile acyl migration of the corresponding pure beta-1
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Nuclear magnetic resonance (NMR) and quantitative structure–activity relationship (QSAR) studies on the transacylation reactivity of model 1β-O-acyl glucuronides. II: QSAR modelling of the reaction using both computational and experimental NMR parameters
S. J. Vanderhoeven,J. Troke,George E. Tranter,Ian D. Wilson,Jeremy K. Nicholson,John C. Lindon +5 more
TL;DR: The overall degradation reaction rates for this series of compounds have been modelled successfully using Hammett substituent constants, computational chemistry-derived partial atomic charges and the experimentally determined carbonyl carbon 13C-NMR chemical shifts of the benzoic acids and their ethyl and glucuronide esters.
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19F and 1H magnetic resonance strategies for metabolic studies on fluorinated xenobiotics: application to flurbiprofen [2-(2-fluoro-4-biphenylyl)propionic acid].
TL;DR: Strategies for the use of 1H and 19F NMR spectroscopy as an aid to the study of the metabolic fate of fluorinated drugs are discussed with reference to the application of these methods to flurbiprofen metabolism in man.
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