J. Tiebes
Radboud University Nijmegen
8 Papers
198 Citations
J. Tiebes is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Total synthesis & Michael reaction. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of J. Tiebes include University of California, San Diego & Scripps Research Institute.
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Papers
The relationship of brevetoxin ‘length’ and A-ring functionality to binding and activity in neuronal sodium channels
Robert E. Gawley,Kathleen S. Rein,Gerhard Jeglitsch,David J. Adams,Emmanuel A. Theodorakis,Emmanuel A. Theodorakis,J. Tiebes,J. Tiebes,Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Daniel G. Baden +10 more
TL;DR: A detailed model for the binding of brevetoxins to the channel is proposed which explains the differences in the effects of the brevetoxin analogs, and offers the potential for developing brevet toxin antagonists.
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Total Synthesis of Brevetoxin B. 3. Final Strategy and Completion
Kyriacos C. Nicolaou,Floris P. J. T. Rutjes,Emmanuel A. Theodorakis,J. Tiebes,M. Sato,E. Untersteller +5 more
TL;DR: The final strategy for the total synthesis of brevetoxin B (1) according to the retro synthetic analysis shown in Scheme 1 is described in this paper, where the synthesis strategy is described.
Total Synthesis of Brevetoxin-B .2. 2nd Generation Strategies and Construction of the Dioxepane Region [Defg]
Kyriacos C. Nicolaou,Emmanuel A. Theodorakis,Floris P. J. T. Rutjes,M. Sato,J. Tiebes,X.‐Y. Xiao,C.-K. Hwang,M. E. Duggan,Zhen Yang,Elias A. Couladouros,F. Sato,Jongheon Shin,H.‐M. He,T. Bleckman +13 more
TL;DR: The second generation strategy for the total synthesis of brevetoxin B (1) is presented in this paper, where the Yamaguchi lactonization was successfully applied for the formation of the EFG and (DEFG) lactones (15 -* 7) and (29 6), respectively.
RCM-mediated synthesis of fluorinated cyclic hydrazines
TL;DR: A series of fluorinated cyclic hydrazine derivatives has been prepared in a straightforward manner using ring-closing me-tathesis (RCM) of trifluoromethylated olefins as the key step as mentioned in this paper.
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