J. Smith
6 Papers
J. Smith is an academic researcher. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 2, co-authored 6 publications.
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Papers
The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities
Eric Venner,Karynne E. Patterson,Divya Kalra,Marsha M. Wheeler,Y.-J. Chen,Salima Kalla,B. Yuan,Jason H. Karnes,Kimberly Walker,J. Smith,Sean McGee,Anjana Radhakrishnan,Anis Haddad,P. Empey,Q. Wang,G. Jarvik,Diana M. Toledo,Anjene Musick,Raphael Gibbs,The All of Us Research Program +19 more
TL;DR: In this article , the authors grouped participants by computed genetic ancestry and summarized the frequency of pathogenic variation within these groups and found that the European subgroup showed the highest rate of pathogen variation (2.1%), with other ancestry groups ranging from 1.04% (East Asian) to 1.87% ('Other').
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The association between mitochondrial DNA copy number, low-density lipoprotein cholesterol, and cardiovascular disease risk
X L Liu,X. Sun,Y Zhang,Ming May Lai,Kerri L. Wiggins,L. Raffield,Lawrence F. Bielak,Wei Zhao,Achilleas N. Pitsillides,Jeffrey Haessler,Yu Zheng,Thomas W. Blackwell,J. Yao,Xu Guo,Yafang Qian,Bharat Thyagarajan,Nathan Pankratz,Steve Rich,Kent D. Taylor,Patricia A. Peyser,S. Heckbert,Sudha Seshadri,Eric Boerwinkle,M. Grove,Nicholas B. Larson,J. Smith,Vinitha Ramachandran,A. Fitzpatrick,Myriam Fornage,Jun Ding,April P. Carson,G. Abecasis,Josée Dupuis,Alexander P. Reiner,Charles Kooperberg,L. Hou,B. M. Psaty,J. S. Wilson,Daniel Levy,J. Rotter,J. C. Bis,Claudia L. Satizabal,D. Arking,C. Liu +43 more
TL;DR: High LDL underlies the complex relationships between vascular atherosclerosis and lower mtDNA CN, and finds no evidence supporting a causal association for lower mt DNA CN with higher CHD risk or higher LDL, but bi-directional univariable and multivariable MR analyses provided strong evidence indicating higher LDL level is causally associated with lower mitochondrial DNA copy number, and CHD was weakly associated with higher mtDNACN.
Circulating Metabolites May Illustrate Relationship of Alcohol Consumption with Cardiovascular Disease
Yang Li,Mo Wang,X Liu,Jian Rong,Patricia E. Miller,Roby Joehanes,Tianxiao Huan,X. Guo,Jerome I. Rotter,J. Smith,B Yu,Matthew Nayor,Diane Levy,C. Liu,J. Ma +14 more
TL;DR: In this article , the authors used linear mixed models to investigate the associations of alcohol consumption with 211 log-transformed plasma metabolites, adjusting for age, sex, batch, smoking, diet, physical activity, BMI, and familial relationship.
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Peer Review
Open Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
C. Christiansen,A. D. Relloso,W. Zhao,Julia S. El-Sayed Moustafa,Pei-Chen Tsai,JM Maddock,Karin Haack,Shelley A. Cole,Sharon L.R. Kardia,Mariam Molokhia,Matthew Suderman,Chris Power,Caroline L Relton,Anson Wong,Diana Kuh,Ashley Goodman,Kerrin S. Small,J. Smith,M. T. Plaza,Ana Navas-Acien,G. Ploubidis,Rebecca Hardy,Jordana T. Bell +22 more
TL;DR: Novel smoking‑associated signals on the EPIC array are identified as possible biomarkers of exposure to smoking and may help improve the understanding of smoking‑related disease risk.
Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study
Laurence J. Howe,Humaira Rasheed,P. Jones,Dorret I. Boomsma,David M. Evans,Alexandros Giannelis,Caroline Hayward,John L. Hopper,Hannu Lahtinen,S. Li,Penelope A. Lind,Nicholas G. Martin,Pekka Martikainen,S. E. Medland,Tim T Morris,Michel G. Nivard,Jean-Baptiste Pingault,Karri Silventoinen,J. Smith,Emily A. Willoughby,J. F. Wilson,Within Family Consortium,Bjørn Olav Åsvold,O. Naess,George Davey Smith,Jaakko Kaprio,B. Brumpton,Neil M Davies +27 more
TL;DR: Both population and within-sibship MR estimates provided evidence that educational attainment influences BMI, cigarette smoking and SBP, and genetic variant-educational attainment associations also attenuated to a similar extent.