The chemical interpretation and practice of linear solvation energy relationships in chromatography

Micellar liquid chromatography (MLC) is an analytical technique belonging to the wide range of reversed-phase liquid chromatographic (RP-LC) separation techniques. MLC with the use of surfactant solutions above its critical micellar concentration (CMC) and the addition of organic modifiers is currently an important analytical tool with still growing theoretical considerations and practical applications in pharmaceutical analysis of drugs and other biologically active compounds. The use of MLC as an alternative, relatively much faster in comparison to conventional chromatographic separation techniques has several advantages, especially as being suitable for screening pharmaceutical analysis. The analytical data received from MLC analysis are considered a useful source of information to predict passive drug absorption, drug transport and other pharmacokinetics and physicochemical measures of pharmaceutical substances.

Recent theoretical and practical applications of micellar liquid chromatography (MLC) in pharmaceutical and biomedical analysis

The potential of liposome electrokinetic chromatography (LEKC), which is applied to estimate compound penetration through the skin, was evaluated in this report. Quantitative retention-activity relationships (QRARs) were successfully constructed between the compound skin permeability coefficient (log Kp) and the retention values (log k), as well as some calculated molecular descriptors by the stepwise regression method (R2 = 0.902). Furthermore, the developed vector method was applied to compare the similarity between the reported lipophilicity measuring scales and compounds through the skin. Both results indicated that the transport of a compound into the liposomal membrane was more similar to its penetration through the skin than that into other systems including the octanol–water system. In a word, LEKC is a promising simple method to predict drug penetration through the skin.

Predicting skin permeability using liposome electrokinetic chromatography.

Characterization of microemulsion liquid chromatography systems by solvation parameter model and comparison with other physicochemical and biological processes

Solute-solvent interactions in micellar liquid chromatography. Characterization of hybrid micellar systems of sodium dodecyl sulfate-pentanol.

Study of retention in micellar liquid chromatography on a C8 column by the use of linear solvation energy relationships.

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Study of retention in micellar liquid chromatography on a C8 column by the use of linear solvation energy relationships.