Objetivos.El estudio de la concentracion de N-acetil-aspartato (NAA) proporciona datos interesantes sobre las alteraciones corticales en las enfermedades psicoticas. Aunque la reduccion de la concentracion de NAA en la corteza cerebral es un resultado habitual en la esquizofrenia cronica, es menos constante en la enfermedad bipolar. Por otra parte, es probable que los valores de NAA puedan ser diferente en hombres y mujeres con esquizofrenia.Metodos.Mediante con espectroscopia por resonancia magnetica protonica ('H MRS) calculamos las concentraciones de NAA en la corteza prefrontal de dos grupos de hombres, uno con esquizofrenia (n = 11) y otro con trastorno bipolar (n = 13) de similar duracion y los comparamos con una muestra de hombres sanos que usamos como grupo control (n = 10). Ademas, comparamos el grado de desviaciones estructurales de los volumenes normales de sustancia gris (SG) y liquido cefalorraquideo (LCR) en la corteza prefrontal dorsolateral.Resultados.Comparados con los controles, los pacientes con esquizofrenia y trastorno bipolar tuvieron un cociente NAA/creatina mas bajo, y solo el grupo de pacientes con esquizofrenia mostro un aumento de LCR en la region prefrontal dorsolateral. No hubo ninguna diferencia entre los grupos en el cociente colina/creatina.Conclusiones.Estos datos sugieren que la disminucion de NAA en la region prefrontal pueda ser similar en la esquizofrenia y en el trastorno bipolar, al menos, en estados cronicos. Sin embargo, el LCR cortical puede aumentar significativamente en pacientes con esquizofrenia.

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D7340AD053867AA4F00599107B5964B7/S1134066500004987a.pdf/div-class-title-concentracion-de-n-acetil-aspartato-en-el-area-prefrontal-dorsolateral-en-hombres-con-esquizofrenia-cronica-y-trastorno-bipolar-cronico-div.pdf

Concentración de N-acetil-aspartato en el área prefrontal dorsolateral en hombres con esquizofrenia crónica y trastorno bipolar crónico

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Concentración de N-acetil-aspartato en el área prefrontal dorsolateral en hombres con esquizofrenia crónica y trastorno bipolar crónico