THE use of digitalis marks the beginning of the modern era of cardiac therapy. Whole-leaf digitalis and the purified derivatives, the cardiac glycosides, continue as the most effective medicinal ag...

Current Concepts in Digitalis Therapy

Drug-induced systemic lupus erythematosus: a critical review.

Compared to procainamide in an animal arrhythmic model, the antiarrhythmic potency of the N-acetylated metabolite of procainamide (NAPA) was 92% with respect to dose and 70% with respect to plasma level. The antiarrhythmic effects of combinations of the drugs were additive. Measurements of procainamide and NAPA plasma levels needed to suppress ventricular extrasystoles suggested that both compounds are nearly equipotent in patients as well. The average plasma level required for arrhythmia control in these patients was equivalent to 5.1 mcg/ml procainamide. Since patients on long-term procainamide therapy have plasma concentrations of NAPA that are usually comparable to, and occasionally greater than, their procainamide levels, dose regiments based on procainamide levels alone need revision to include consideration of the levels of this metabolite.

Antiarrhythmic potency of N-acetylprocainamide.

The use of procaine amide and lidocaine in the treatment of cardiac arrhythmias.

Abstract Twenty patients with ventricular arrhythmias were treated with procaine amide to determine an antiarrhythmic plasma drug concentration range and to observe procaine amide's effect on blood...

Intermittent intravenous procaine amide to treat ventricular arrhythmias. Correlation of plasma concentration with effect on arrhythmia, electrocardiogram, and blood pressure.

Procaine amide, a new synthetic analogue of procaine, has marked antiarrythmic activity and is relatively stable in the body. It is effective when administered orally or intravenously, and has few toxic effects in therapeutic doses. The drug has been used successfully in the suppression of ventricular premature contractions and in the interruption of ventricular tachycardia. Some patients treated successfully with procaine amide had been given quinidine to the point of toxicity without affecting the aberrant rhythm. Procaine amide appears to be less effective in interrupting auricular than ventricular arrhythmias.

The Use of Procaine Amide in Cardiac Arrhythmias

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The Use of Procaine Amide in Cardiac Arrhythmias