J. McCool
Tufts University
8 Papers
16 Citations
J. McCool is an academic researcher from Tufts University. The author has contributed to research in topics: Fibroin & Guanine nucleotide exchange factor. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of J. McCool include Harvard University.
Chat about Author
Papers
The inflammatory responses to silk films in vitro and in vivo
Lorenz Meinel,Sandra Hofmann,Sandra Hofmann,Vassilis Karageorgiou,Carl A. Kirker-Head,J. McCool,Gloria Gronowicz,Ludwig Zichner,Robert Langer,Gordana Vunjak-Novakovic,David L. Kaplan +10 more
TL;DR: Biocompatibility studies of silk films (with or without covalently bound RGD) that were seeded with bone-marrow derived mesenchymal stem cells and cultured in vitro with human MSC suggest that purified degradable silk is biocompatible and the in vitro cell culture model gave inflammatory responses that were comparable to those observed in vivo.
814
Safety of, and biological and functional response to, a novel metallic implant for the management of focal full-thickness cartilage defects: Preliminary assessment in an animal model out to 1 year
TL;DR: The safety of, and biological and functional response to, a metallic resurfacing implant which may delay or obviate the need for traditional arthroplasty is assessed.
93
Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis
TL;DR: A cAMP/cAMP-GEF/Rap/PI3-kinase/Akt signaling pathway may confer protection against bile acid- and Fas-induced apoptosis in hepatocytes and that activation of cAMP- GEFs promotes Akt phosphorylation and hepatocyte survival.
57
Mechanical evaluation of a porous bone graft substitute based on poly(propylene glycol-co-fumaric acid)
David D. Hile,Carl A. Kirker-Head,Carl A. Kirker-Head,Stephen A. Doherty,Michael P. Kowaleski,Michael P. Kowaleski,J. McCool,J. McCool,D L Wise,Debra J. Trantolo +9 more
TL;DR: PPF-based bone-graft substitute increased the flexural strength of K-wire stabilized osteotomies and suggest that this type of bone graft substitute may have clinical utility in the stabilization of complex tubular bone fractures.
11
Corrigendum to “Silk based biomaterials to heal critical sized femur defects” [Bone 39 (2006) 922–931]
Lorenz Meinel,O. Betz,Roberto J. Fajardo,Sandra Hofmann,Sandra Hofmann,A. Nazarian,E. Cory,M. Hilbe,J. McCool,Robert Langer,Gordana Vunjak-Novakovic,Gordana Vunjak-Novakovic,Hans P. Merkle,Brigitte von Rechenberg,David L. Kaplan,Carl A. Kirker-Head +15 more
3