J. M. Salbaum
University of Cologne
14 Papers
75 Citations
J. M. Salbaum is an academic researcher from University of Cologne. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 5 publications.
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Papers
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Jie Kang,H. G. Lemaire,A. Unterbeck,J. M. Salbaum,Colin L. Masters,K.-H. Grzeschik,Gerd Multhaup,Konrad Beyreuther,Benno Müller-Hill +8 more
TL;DR: An apparently full-length complementary DNA clone coding for the A4 polypeptide is isolated and sequenced and suggests that the cerebral amyloid deposited in Alzheimer's disease and aged Down's syndrome is caused by aberrant catabolism of a cell-surface receptor.
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Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.
Katrin Zimmermann,T. Herget,J. M. Salbaum,W. Schubert,C. Hilbich,Matthias Cramer,Colin L. Masters,Gerd Multhaup,Jie Kang,H. G. Lemaire +9 more
TL;DR: It is demonstrated by in situ hybridization that pre‐A4 mRNA is present in adult human muscle, in cultured human myoblasts and myotubes, and the selective localization of the protein on distinct nuclear envelopes could reflect an interaction with motor endplates.
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Cross-Omics Analysis of Fenugreek Supplementation Reveals Beneficial Effects Are Caused by Gut Microbiome Changes Not Mammalian Host Physiology
Katarina A. Jones,Allison J. Richard,J. M. Salbaum,Susan Newman,Richard P. Carmouche,Sarah Webb,Annadora J. Bruce-Keller,Jacqueline M. Stephens,Shawn R. Campagna +8 more
TL;DR: Untargeted metabolomics revealed metabolic processes affected by fenugreek and showed broad ranging impacts in multiple pathways, including carnitine biosynthesis, cholesterol and bile acid metabolism, and arginine biosynthetic pathways, which may play important roles in the beneficial effects of fenUGreek.
Effects of Maternal Diabetes and Diet on Gene Expression in the Murine Placenta
TL;DR: The results reinforce the notion that the exposure to maternal diabetes has particularly pronounced effects on gene expression at midgestation time points and suggest mechanisms underlying developmental programming act early in pregnancy, during placenta morphogenesis, and before the conceptus switches from histiotrophic to hemotrophic nutrition.
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