Any use of fluorides, whether systemic or topical, in caries prevention and treatment in children results in ingestion and absorption of fluoride into the blood circulation. The mineralization of teeth under formation may be affected so that dental fluorosis may occur. Dental fluorosis reflects an increasing porosity of the surface and subsurface enamel, causing the enamel to appear opaque. The clinical features represent a continuum of changes ranging from fine white opaque lines running across the tooth on all parts of the enamel to entirely chalky white teeth. In the latter cases, the enamel may be so porous (or hypomineralized) that the outer enamel breaks apart posteruptively and the exposed porous subsurface enamel becomes discolored. These changes can be classified clinically by the TF index to reflect, in an ordinal scale, the histopathological changes associated with dental fluorosis. Compared with Dean's and the TSIF index, we consider the TF index to be more precise. Recent studies on human enamel representing the entire spectrum of dental fluorosis have demonstrated a clear association between increasing TF score and increasing fluoride content of the enamel. So far, no useful data on dose (expressed in mg fluoride/kg b.w.)-response (dental fluorosis) relationships are available. In this paper, we have, therefore, re-evaluated the original data by Dean et al. (1941, 1942), Richards et al. (1967), and Butler et al. (1985) from the USA, by applying the equation of Galagan and Vermillion (1957) which permits the calculation of water intake as a function of temperature.(ABSTRACT TRUNCATED AT 250 WORDS)

The nature and mechanisms of dental fluorosis in man.

Fluoride (F) is an essential element for animal growth, not readily taken up by plants from soils, yet cases of acute fluorosis in grazing animals caused by ingestion of phosphatic fertilisers, volcanic ash, and industrial wastes remind us of its potential hazard. Fluoride concentrations in topsoils slowly increase where annual inputs through atmospheric pollution and phosphatic fertilisers exceed losses. This paper reviews information on the fate of F in grazed pasture systems with the aim of assessing the potential toxicity of accumulating soil F. A preliminary F‐cycling model for grazed pastures, based on the review of international literature and F concentrations in selected New Zealand pasture soils, indicated that grazing sheep and cattle obtain over 50% of their dietary F (and this may be >80% during winter) from soil ingestion. The model suggests that at the extremes of the ranges of the measured winter soil ingestion (143–300 g d‐1 for sheep and 900–1600 g d‐1 for cattle) and dietary F a...

https://www.tandfonline.com/doi/pdf/10.1080/00288233.2000.9513430

Fluoride: A review of its fate, bioavailability, and risks of fluorosis in grazed‐pasture systems in New Zealand

Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies (NDA) on a request from the Commission related to the Tolerable Upper Intake Level of Fluoride

https://pure.aber.ac.uk/portal/files/29074535/Fluorine_manuscript.pdf

Fluorine in the environment, a review of its sources and geochemistry

Natural and anthropogenic factors affecting groundwater quality of an active volcano (Mt. Etna, Italy)

Fluorides : effects on vegetation, animals and humans

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Fluorides : effects on vegetation, animals and humans