J. Heller
Systems Research Institute
19 Papers
393 Citations
J. Heller is an academic researcher from Systems Research Institute. The author has contributed to research in topics: Drug carrier & Controlled release. The author has an hindex of 14, co-authored 19 publications. Previous affiliations of J. Heller include Pacific Research Institute.
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Papers
Release of BSA from poly(ortho ester) extruded thin strands.
Alexandra Rothen-Weinhold,K. Schwach-Abdellaoui,John Barr,S.Y. Ng,Hui-Rong Shen,Robert Gurny,J. Heller +6 more
TL;DR: In vitro erosion and BSARelease results indicate that after a fairly long lag-time, BSA release and polymer erosion occur concomitantly indicating an erosion-controlled process.
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Control of Molecular Weight for Auto-Catalyzed Poly(ortho ester) Obtained by Polycondensation Reaction
TL;DR: In this paper, the use of n-decanol during the polymerization as a chain stopper allows good control of polymer molecular weight and thermal and viscoelastic properties of such polymers as well as their molecular weight distribution are also reported.
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Concomitant and controlled release of dexamethasone and 5-fluorouracil from poly(ortho ester).
Suzanne Einmahl,Monia Zignani,Emmanuel Varesio,J. Heller,Jean-Luc Veuthey,Cyrus Tabatabay,Robert Gurny +6 more
TL;DR: The combination of 5-fluorouracil and dexamethasone phosphate allows a sustained and concomitant release of both drugs, due to the basic characteristics of the corticosteroid which stabilize the polymer.
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A viscous bioerodible poly(ortho ester) as a new biomaterial for intraocular application.
Suzanne Einmahl,Francine Behar-Cohen,Cyrus Tabatabay,M. Savoldelli,François D'Hermies,D. Chauvaud,J. Heller,Robert Gurny +7 more
TL;DR: POE appears to be a promising biomaterial for clinical intraocular application and the presence of modulators of degradation both improved POE biocompatibility and prolonged polymer lifetime in the eye.
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Bioerodible polymers for ocular drug delivery.
TL;DR: Polymers from all three classes of Bioerodible polymers have been divided into three classes based on their mechanism of hydrolysis: Type I--hydrolysis of crosslinked hydrogels; Type II--solubilization by ionization or hydrolyses of linear polymers; and Type III--biodegradation by backbone cleavage.
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