Oxidative Prozesse spielen neben osmotischen Prozessen und Veranderungen der Kristalline eine bedeutende Rolle bei der Kataraktentstehung (s. J. Graw: ,,Beteiligung oxidativer Prozesse bei der Kararaktentstehung“, S. 125). Bei der Untersuchung von Kataraktmutanten ist es deshalb wichtig, Parameter zu finden, die Hinweise auf die Beteiligung der verschiedenen Prozesse geben konnen. Als Indikatoren fur eine oxidative Belastung benutzten fruhere Untersuchungen an der Modellmutante Nop [1, 2] oxidiertes Glutathion (GSSG) sowie die Enzyme Superoxiddismutase (SOD), Glutathionreduktase, Glutathionperoxidase, Katalase und Glucose-6-Phosphat-Dehydrogenase. Da nur GSSG und SOD bei der Mutante Nop Veranderungen zeigten, wurden an einer Reihe von dominanten Kataraktmutanten aus Bestrahlungsversuchen diese Parameter untersucht; erste Ergebnisse werden dargestellt.

Oxidative Prozesse in Linsen verschiedener dominanter Kataraktmutanten der Maus

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Oxidative Prozesse in Linsen verschiedener dominanter Kataraktmutanten der Maus