Influence of silica surface chemistry and structure on the properties, structure and coverage of alkyl-bonded phases for high-performance liquid chromatography

Influence of substrate parameters on column selectivity with alkyl bonded-phase sorbents

In this second part of the review heterogeneity of the silica surface is described and evidence is presented for the existence of a low population of strong adsorption sites. Methods of detection and determination of these strongly interacting sites are discussed. The last part of the review is devoted to the suppression of unwanted adsorption activity. Methods of blockage and special methods for the preparation of HPLC packings are described.

Silica surface controversies, strong adsorption sites, their blockage and removal. Part II

The influence of silica structure on reversed-phase retention

Performance of polymer-coated silica C18 packing materials prepared from high-purity silica gel : The suppression of undesirable secondary retention processes

Trace elements in different silica gels are determined by neutron activation analysis. The presence of 20 elements in the ppm range and of 15 elements in the ppb range is established in all silica gels; even in spherical material probably obtained via an organosilicium starting material. Removal of these elements by acid treatment before and after derivatization to a reversed-phase is studied. This is only partially effective. The resulting HPLC phases are, however, much better in cases where trace elements are detrimental. Even octadecyl derivatized silicagel can withstand boiling in 12 N hydrochloric acid without loosing significant amounts of bonded organic material.

Trace elements in HPLC silica gel

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Trace elements in HPLC silica gel