J. Evans
University of Leicester
2 Papers
J. Evans is an academic researcher from University of Leicester. The author has contributed to research in topics: HMG-CoA reductase & Placebo. The author has an hindex of 2, co-authored 2 publications.
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Papers
Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue.
TL;DR: A 40% reduction in MMP-9 levels in the AAA wall in patients randomised to simvastatin provides a possible molecular mechanism to explain the reportedly beneficial effects of statins to slow AAA growth.
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HMG-CoA reductase inhibitors (statins) decrease MMP-3 and MMP-9 concentrations in abdominal aortic aneurysms.
TL;DR: Investigation of the in vivo effect of statins on MMP levels in AAA demonstrates that statins decrease MMP-9 and M MP-3 levels and represent a potential pharmacotherapy in established AAA.
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