J. E. Vivienne Watson
Amgen
4 Papers
J. E. Vivienne Watson is an academic researcher from Amgen. The author has contributed to research in topics: Biology & Cell. The author has an hindex of 2, co-authored 2 publications.
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Papers
Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages.
Michael A. Gonzalez,Daniel R. Lu,Maryam Yousefi,Ashley Kroll,Chen Hao Lo,Carlos G. Briseño,J. E. Vivienne Watson,Sergey V. Novitskiy,Vanessa Arias,Hong Zhou,Min K. Tsai,Emily Ashkin,Christopher W. Murray,Chi Ming Li,Monte M. Winslow,Kristin V. Tarbell +15 more
TL;DR: In this article , the authors utilized both syngeneic and novel autochthonous lung tumor models in which neoplastic cells expressed the fluorophore tdTomato (tdTom) to identify TAMs that have phagocytosed neplastic cells in vivo.
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Use of Cryopreserved Cell Aliquots in the High-Throughput Screening of Small Interfering RNA Libraries
Elissa Swearingen,Flordeliza Fajardo,Xiangyun Wang,J. E. Vivienne Watson,Kim Quon,Paul D. Kassner +5 more
TL;DR: The authors have developed a system using frozen cell aliquots to use in siRNA HTS, so that a major source of variability introduced into cell-based screens can be standardized.
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Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
Magnus I. Magnusson,Bjarni A. Agnarsson,Jon G. Jonasson,Thordur Tryggvason,Famke Aeffner,Louise le Roux,Droplaug N Magnusdottir,Helga S Gunnarsdottir,Kristin Alexiusdottir,Kristbjorg Gunnarsdottir,Emilía Söebech,Hjaltey Runarsdottir,Erna M Jonsdottir,Bjarney S Kristinsdottir,Sigurgeir Olafsson,Hildur Knutsdottir,Unnur Thorsteinsdottir,Magnus O. Ulfarsson,Daniel F. Gudbjartsson,Jona Saemundsdottir,Olafur T. Magnusson,Gudmundur L. Norddahl,J. E. Vivienne Watson,Thorunn Rafnar,Sigrun H. Lund,Kari Stefansson +25 more
TL;DR: Tumour stroma and lymphocytic infiltration variables are strongly associated with prognosis of CRC and capture the prognostic effects of tumour mutation status, and Elevated levels of two plasma proteins, CA-125 and PPP1R1A, associate with a worse prognosis.
Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability
Karen Rex,Shawn M. Jeffries,Matthew L. Brown,Timothy J. Carlson,Angela Coxon,Flordeliza Fajardo,Brendon Frank,Darin J. Gustin,Alexander Kamb,Paul D. Kassner,Shyun Li,Yihong Li,Kurt Morgenstern,Matthew H. Plant,Kim Quon,Astrid Ruefli-Brasse,Joanna Schmidt,Elissa Swearingen,Nigel Walker,Zhulun Wang,J. E. Vivienne Watson,Dineli Wickramasinghe,Mariwil Wong,Guifen Xu,Holger Wesche +24 more
TL;DR: The results show that the SPHK rheostat does not play a major role in tumor cell viability, and that SPHKs might not be attractive targets for pharmacological intervention in the area of oncology.